Revisão Revisado por pares

From AIDS to Parasite Infection: Pathogen‐Mediated Subversion of Programmed Cell Death as a Mechanism for Immune Dysregulation

1994; Wiley; Volume: 142; Issue: 1 Linguagem: Inglês

10.1111/j.1600-065x.1994.tb00882.x

ISSN

1600-065X

Autores

Jean Claude Ameisen, Jérôme Estaquier, Thierry Idziorek,

Tópico(s)

Immune responses and vaccinations

Resumo

Immunological ReviewsVolume 142, Issue 1 p. 9-51 From AIDS to Parasite Infection: Pathogen-Mediated Subversion of Programmed Cell Death as a Mechanism for Immune Dysregulation Jean Claude Ameisen, Corresponding Author Jean Claude Ameisen INSERM U415 Pathogenese du sida et des infections a tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, France Faculte de Medecine, Universite Lille II, 59049 Lille, France.J. C. Ameisen, INSERM U415, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, France; Telephone: [33] 2052 3239; Fax: [33] 2052 32 39 or [33] 2087 7906.Search for more papers by this authorJerome Estaquier, Jerome Estaquier INSERM U415 Pathogenese du sida et des infections a tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, FranceSearch for more papers by this authorThierry Idziorek, Thierry Idziorek INSERM U415 Pathogenese du sida et des infections a tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, FranceSearch for more papers by this author Jean Claude Ameisen, Corresponding Author Jean Claude Ameisen INSERM U415 Pathogenese du sida et des infections a tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, France Faculte de Medecine, Universite Lille II, 59049 Lille, France.J. C. Ameisen, INSERM U415, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, France; Telephone: [33] 2052 3239; Fax: [33] 2052 32 39 or [33] 2087 7906.Search for more papers by this authorJerome Estaquier, Jerome Estaquier INSERM U415 Pathogenese du sida et des infections a tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, FranceSearch for more papers by this authorThierry Idziorek, Thierry Idziorek INSERM U415 Pathogenese du sida et des infections a tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. Albert Calmette, 59019 Lille, FranceSearch for more papers by this author First published: December 1994 https://doi.org/10.1111/j.1600-065X.1994.tb00882.xCitations: 68AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Actor, J. K., Shirai, M., Kullberg, M. C, Buller, R. M. L., Sher, A. & Berzofski, J. A. (1993) Helminth infection results in decreased virus-specific CD8 cytotoxic T cell and THl cytokine responses as well as delayed virus clearance. Proc. Natl. Acad. Sci. USA 90, 948. Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M. & Oldstone, M. B. A. (1984) Selection of genetic variants of lymphocytic choriomenengitis virus in spleens of persistently infected mice: role of suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med 60, 521. Akbar, A. N., Borthwick, N., Salmon, M., Gombert, W., Bofill, M., Shamsadeen, N., Pilling, D., Pett, S., Grundy, J. E. & Janossy, G. (1993) The significance of low bcl-2 expression by CD45RO+ T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J. Exp. Med 178, 427. Ameisen, J. C. (1992) Programmed cell death and AIDS: from hypothesis to experiment. Immunol. Today 13, 388. Ameisen, J. C. (1994) Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer. AIDS 8, 1197. Ameisen, J. C. & Capron, A. (1991) Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunol. Today 12, 102. Ameisen, J. C, Estaquier, J., Idziorek, T. & De Bels, E (1995) The relevance of apoptosis to AIDS pathogenesis. Trends in Cell Biology in press. Arthur, L. O., Bess, J. W, Sowder II, R. C, Benveniste, R. E., Mann, D. L., Chermann, J. C. & Henderson, L. E. (1992) Cellular proteins bound to immunodeficiency viruses: Implications for pathogenesis and vaccines. Science 258, 1935. Banda, N. K., Bernier, I, Kurahara, D. K., Kurrle, R., Haigwood, N., Sekaly, R. P & Finkel, T. H. (1992) Crosslinking CD4 by HIV gpl20 primes T cells for activation-induced apoptosis. J. Exp. Med. 176, 1099. Baskin, G. B., Murphey-Corb, M., Martin, L. N., Davison-Fairburn, B., Hu, F. S. & Kuebler, D. (1991) Thymus in simian immunodeficiency virus infected rhesus monkeys. Lab. Invest. 65, 400. Bell, D. A., Morrison, B. & Vandenbygaart, P. (1990) Immunogenic DNA-related factors: Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes. J. Clin. Invest. 85, 1437. Bishop, S. A., Gruffydd-Jones, T. J., Harbour, D. A. & Stokes, C. R. (1993) Programmed cell death (apoptosis) as a mechanism of cell death in PBMC from cats infected with feline immunodeficiency virus (EIV). Clin. Exp. Immunol. 93, 65. Blackman, M., Kappler, J. & Marrack, P. (1990) The role of T-cell receptor in positive and negative selection of developing T cells. Science 248, 1335. Bonyhadi, M. L., Rabin, L., Salimi, S., Brown, D. A., Kosek, J., McCune, J. M. & Kaneshima, H. (1993) HIV induces thymus depletion in vivo. Nature 363, 728. Bretscher, P & Cohn, M. (1970) A theory of self-nonself discrimination. Science 169, 1042. Brinchman, J. E. Albert, J. & Vartdal, F (1991) Few infected CD4+ T cells but a high proportion of replication-competent provirus copies in asymptomatic HIV-1 infection. J. Virol. 65, 2019. Burnet, F. M. (1959) The clonal selection theory of acquired immunity. Cambridge University Press, New York . Burny, A., Hermans, P., Kiermer, V, VanHulle, C, Deschamps, M., Zhang, J., Bex, F, Wolf, H., Sonigo, P & Ameisen, J. C. (1994) Vaccination against HIV/SIV infection and disease: multiple aspects of a complex picture. In: Retroviruses of human AIDS and related animal diseases (VIII Colloque des Cent Gardes. 1993), eds. M. Girard & L. Valette, M. Fondation Merieux, Lyon, France . p. 221. Cameron, P. U., Pope, M., Gezelter, S. & Steinman, R. M. (1994) Infection and apoptotic cell death of CD4 T cells during an immune response to HIV-1-pulsed dendritic cells. AIDS Res. Hum. Retrovir. 10, 61. Capron, A. R. (1992) Immunity to schistosomes. Curr. Op. Immunol. 4, 419. Caspar, P., Grzych, J. M., Lewis, F. & Sher, A. (1991) Downregulation of THl cytokine production accompanies induction of TH2 responses by a parasite helminth S. mansoni J. Exp. Med. 173, 159. Chehimi, J., Starr, S. E., Frank, I., D'Andrea, A., Ma, X., MacGregor, R. R., Sennelier, J. & Trinchieri, G. (1994) Impaired IL-12 production in HIV-infected patients. J. Exp. Med. 179, 1361. Choi, Y. W., Kappler, J. W. & Marrack, P. (1991) A superantigen encoded in the open reading frame of the 3′ long terminal repeat of MMTV. Nature 350, 203. Clem, R. J., Fechheimer, M. & Miller, L. K. (1991) Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 254, 1388. Clerici, M., Lucey, P, Berzofsky, J., Pinto, L., Wynn, T, Blatt, S., Dolan, M., Hendrix, C, Wolf, S. & Shearer, G. (1993) Restoration of HIV-specific cell-mediated immune response by IL-12 in vitro. Science 262, 1721. Clerici, M., Sarin, A., Henkart, P & Shearer, G. M. (1994) Cell mediated immunity in HIV infection. Biotec (Special issue: Proceedings of "Biotech AIDS'94". Florence) 9, 53. Clerici, M. & Shearer, G. (1993) A TH1/TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14, 107. Clerici, M., Stocks, N. I., Zajac, R. A., Boswell, R. N., Bernstein, D. C, Mann, D. L., Shearer, G. M. & Berzofsky, J. A. (1989a) Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HlV-sero-positive individuals Nature 339, 383. Clerici, M., Stocks, N. I., Zajac, R. A., Boswell, R. N., Lucey, D. R., Via, C. S. & Shearer, G. M. (1989b) Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV-seropositive patients. J. Clin. Invest 84, 1892. Clouston, W. M. & Kerr, J. F.R. (1985) Apoptosis, lymphocytotoxicity and the containment of viral infections. Medical Hypothesis 18, 399. Coffman, R. L., Varkila, K., Scott, P & Chatelain, R. (1991) Role of cytokines in the differentation of CD4 T-cell subsets in vivo. Immunological Reviews 123, 189. Cohen, D. I., Tani, Y., Tian, H., Boone, E., Samelson, L. & Lane, H. C. (1992) Participation of tyrosine phosphorylation in the cytopathic effect of HIV-l. Science 256, 542. Cohen, J. J. (1993) Apoptosis. Immunol. Today 14, 126. Cory, S. (1994) Fascinating death factor. Nature 367, 317. Courgnaud, V, Laure, F., Fultz, P, Montagnier, L., Brechot, C. & Sonigo, P (1992) Genetic differences accounting for evolution and pathogenicity of SIV from a sooty mangabeys monkey after cross-species transmission to a pig-tailed macaque. J. Virol. 66, 414. D'Andrea, A., Aste-Amezaga, M., Valiante, N. M., Ma, X. J., Kubin, M. & Trinchieri, G. (1993) IL-10 inhibits human lymphocyte IFNy production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 9, 1041. Daniel, M. D, Kirchhoff, F, Czajak, S. C, Sehgal, P. K. & Desrosiers, R. C. (1992) Protective effect of a live attenuated-SIV vaccine with deletion in the nef gene. Science 258, 1938. Del Llano, A. M., Amieiro-Puig, J. P, Kraiselburd, E. N., Kessler, M. J., Malaga, C. A. & Lavergne, J. A. (1993) The combined assessment of cellular apoptosis, mitochondrial function and proliferative response to pokeweed mitogen has prognostic value in SIV infection. J. Med. Primatol. 11, 194. Desrosiers, R. C. (1990) The simian immunodeficiency viruses. Annu. Rev. Immunol. 8, 557. DeWaal Malefyt, R., Hannen, J., Spits, H., Roncarolo, M. G., te Velde, A., Figdor, C, Johnson, K., Kastelein, R., Yssel, H. & De Vries, J. E. (1991) IL-10 and viral IL-10 strongly reduce antigen-specific human T-cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174, 915. deWaal Malefyt, R., Yssel, H. & De Vries, J. E. (1993) Direct effects of IL-10 on subsets of human CD4 T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J. Immunol. 150, 4754. Dewhurst, S., Embretson, J. E., Anderson, D. C, Mullins, J. I. & Fultz, P. N. (1990) Sequence analysis and acute pathogenicity of molecularly cloned SIVSmm PBjl4. Nature 345, 636. Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N. & Shevach, E. M. (1993) IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the upregulation of B7 expression. J. Immunol 151, 1224. Duvall, E. & Wyllie, A. H. (1986) Death and the cell. Immunol Today 7, 115. Ellis, R. E., Yuan, J. & Horvitz, H. R. (1991) Mechanisms and functions of cell death. Annual Review of Cell Biology 1, 663. Erard, F., Wild, M. T, Garcia-Sanz, J. A. & Le Gros, G. (1993) Switch of CD8 T cells to noncytolytic CD8−CD4− cells that make TH2 cytokines and help B cells. Science 260, 1802. Estaquier, J. & Ameisen, J. C. (1994) Programmed cell death (apoptosis) and AIDS: Is THl dysfunction and deletion related to an abortive TH1/TH2 switch process? In: Challenges in Modern Medicine. Third International Conference on Cytokines: Basic Principles and Practical Applications, eds. S. Romagnani & K. Abbas Serono Symposia Publications, Rome (in press). Estaquier, J., Idziorek, T, De Bels, F., Barre-Sinoussi, F, Hurtrel, B., Aubertin, A. M., Venet, A., Mehtali, M., Muchmore, E., Michel, P., Mouton, Y., Girard, M. & Ameisen, J. C. (1994) Programmed cell death and AIDS: the significance of T-cell apoptosis in pathogenic and non pathogenic primate lentiviral infections. Proc. Natl. Acad. Sci. USA 91, 9431. Everall, I. P., Luthert, P. J. & Lantos, P. L. (1991) Neuronal loss in the frontal cortex in HIV-infection. Lancet 337, 1119. Fauci, A. S. (1988) The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 239, 617. Fauci, A. S. (1993) Multifactorial nature of HIV disease: implications for therapy. Science 262, 1011. Fauci, A. S. (1994) Multifactorial and multiphasic components of the immunopathogenic mechanisms of HIV disease. In: Retroviruses of Human AIDS and Related Animal Diseases (VIII Collogue des Cent Gardes, 1993), Girard, M. & Valette, L. Fondation M. Merieux, Lyon. p. 81. Flores Villanueva, P. Q, Harris, T. S., Ricklan, D. E. & Stadecker, M. J. (1994) Macrophages from schistosomal egg granulomas induce unresponsiveness in specific cloned THl lymphocytes in vitro and down regulate schistosomal granulomatous disease in vivo. J. Immunol 152, 1847. Fulcher, D. A. & Basten, A. (1994) Reduced life span of anergic self-reactive B cells in a double-transgenic model. J. Exp. Med 179, 125. Fultz, P. N., Me Clure, H. M., Anderson, D. C. & Switzer, W. M. (1989) Identification and biologic characterization of an acutely lethal variant of simian immunodeficiency virus from sooty mangabeys (SIV/SMM). AIDS Res. Hum. Retrovir. 5, 397. Fultz, P. N., Schwiebert, R. S., Su, L. Y. & Salter, M. M. (1994) Total lymphoid irradiation as a novel therapeutic approach for treatment of HIV-induced disease. In: Retroviruses of Human AIDS and Related Animal Diseases (VIII Colloque des Cent Gardes, 1993), eds. M. Girard & L. Valette M. Fondation, Lyon. p. 245. Gazzinelli, R. T, Makino, M., Chattopadhyay, S. K., Snapper, C. M., Sher, A., Hugin, A. W. & Morse III, H. C. (1992) CD4 subset regulation in viral infection. Preferential activation of TH2 cells during progression of retrovirus-induced immunodeficiency in mice. J. Immunol 148, 182. Genis, P., Jett, M., Bernton, E. W, Boyle, T, Gelbard, H. A., Dzenko, K., Keane, R. W, Resnick, L., Mizrachi, Y., Volsky, D. J., Epstein, L. G. & Gendelman, H. E. (1992) Cytokines and arachidonic metabolites produced during HIV-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176, 1703. Golding, H., Shearer, G. M., Hillman, K., Lucas, P., Manischewitz, R. A., Zajac, R. A., Clerici, M., Gress, R. E., Boswell, R. N. & Golding, B. (1989) Common epitope in HIV-1-gp41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV-1-infected individuals. J. Clin. Invest. 83, 1430. Golovkina, T. V., Chervonsky, A., Dudley, J. & Ross, S. (1992) Transgenic mouse mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69, 637. Golstein, P, Ojcius, D. M. & Young, J. D.E. (1991) Cell death mechanism and the immune system. Immunological Reviews 121, 29. Gougeon, M.-L., Garcia, S., Heeney, J., Tschopp, R., Lecoeur, H., Guetard, D., Rame, V, Dauguet, C. & Montagnier, L. (1993) Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retrovir. 9, 553. Gougeon, M.-L., Olivier, R., Garcia, S., Guetard, D, Dragic, T, Dauguet, C. & Montagnier, L. (1991) Mise en evidence d'un processus d'engagement vers la mort cellulaire par apoptose dans les lymphocytes de patients infectes par le VIH. C. R. Acad. Sci. Paris 312, 529. Gray, D. (1994) Regulation of immunological memory. Curr. Opi. Immunol. 6, 425. Graziosi, C, Pantaleo, G., Gantt, K. R., Fortin, J. P, Demarest, J. F., Cohen, O. J., Sekaly, R. & Fauci, A. S. (1994) Lack of evidence for the dichotomy of THl and TH2 predominance in HIV-infected individuals. Science 265, 248. Green, D. R. & Scott, D. W. (1994) Activation-induced apoptosis in lymphocytes. Curr. Op. Immunol. 6, 476. Greenberg, J., Guo, A., Klessig, D. & Ausubel, F. (1994) Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defence functions. Cell 77, 551. Groux, H., Monte, D, Bourez, J. M., Capron, A. & Ameisen, J. C. (1991) L'activation des lymphocytes T CD4+ de sujets asymptomatiques infectes par le VIH entraine le declenchement d'un programme de mort lymphocytaire par apoptose. C R. Acad. Sci. Paris 312, 599. Groux, H., Monté, D, Plouvier, B., Capron, A. & Ameisen, J. C. (1993) CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: respective roles of IL-1, IL-2, IFNγ and accessory cells. Eur. J. Immunol. 23, 1623. Groux, H., Torpier, G., Monté, D., Mouton, Y, Capron, A. & Ameisen, J. C. (1992) Activation-induced death by apoptosis in CD4+ T Cells from HIV-infected asymptomatic individuals. J. Exp. Med. 175, 331. Grzych, J. M., Pearce, E., Cheever, A., Caulada, Z. A., Caspar, P., Heiny, S., Lewis F. & Sher, A. (1991) Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni J. Immunol. 146, 1322. Harrington, E. A., Fanidi, A. & Evan, G. I. (1994) Oncogenes and cell death. Cur. Op. Genetics and Development 4, 120. Heinzel, E, Sadick, S., Mutha, S. & Locksley, M. (1991) Production of IFNγ, IL-2, IL-4 and IL-10 by CD4+ lymphocytes in vivo during healing and progressive leishmaniasis. Proc. Natl. Acad. Sci. USA 88, 7011. Held, W, Acha-Orbea, H., McDonals, H. R. & Waanders, G. A. (1994) Superantigens and retroviral infection: insights from MMTV. Immunol. Today 15, 184. Hofmann, B., Jakobsen, K. D, Odum, N., Dickmeiss, E., Platz, P., Ryder, L. P., Pedersen, C, Mathiesen, L., Bygbjerg, I., Faber, V. & Svejgaard, A. (1989) HIV-induced immunodeficiency relatively preserved PHA as opposed to decreased PWM responses via CD2/PHA pathway. J. Immunol. 142 1874. Howie, S., Sommerfield, A. J., Gray, E. & Harrison, D. J. (1994) Peripheral T lymphocyte depletion by apoptosis after CD4 ligation in vivo: selective loss of CD44− and 'activating' memory T cells. Clin. Exp. Immunol. 95, 195. Hügin, A. W, Vacchio, M. & Morse, H. C. (1991) A virus-encoded superantigen in a retro-virus-induced immunodeficiency syndrom of mice. Science 252, 425. Imberti, L., Sottini, A., Betinardi, A., Puotti, M. & Primi, D. (1991) Selective depletion in HIV infection of T cells that bear specific T cell receptor Vβ sequences. Science 254, 860. Itoh, N., Tsujimoto, Y. & Nagata, S. (1993) Effect of Bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151, 621. Janeway Jr. C. A. (1991) MLS: makes a little sense. Nature 349, 459. Janeway Jr. C. A. (1992) The immune system evolved to discriminate infectious nonself from non infectious self. Immunol. Today 13, 11. Janeway Jr. C. A. & Bottomly, K. (1994) Signals and signs for lymphocyte responses. Cell 76, 275. Jenkins, M. (1992) The role of cell division in the induction of clonal anergy. Immunol. Today 13, 69. Jenkinson, E. J., Kingston, R., Smith, C. A., Williams, G. T. & Owen, J. J. T. (1989) Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T-cell repertoire. Eur. J. Immunol. 19, 2175. Jeurissen, S. H. M., Wagenaar, F, Pol, J. M. A., van der Erb, A. J. & Noteborn, M. H.M. (1992) Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection. J. Virol. 66, 7383. Johnson, B. K., Stone, G. A., Godec, M. S., Asher, D. M., Gadjusek, D. C. & Gibbs Jr. C. J. (1993) Long-term observations of HIV-infected chimpanzees. AIDS Res. Hum. Retrovir. 9, 375. Ju, S. T, Cui, H. L., Panka, D. J., Ettinger, R. & Marshak-Rothstein, A. (1994) Participation of target Fas protein in apoptosis pathway induced by CD4+ TH1 and CD8+ cytotoxic T cells. Proc. Natl. Acad. Sci. USA 91, 4185. Kägi, D., Vignaux, F, Lederman, B., Bürki, K., Depraetere, V, Nagata, S., Hengartner, H. & Golstein, P. (1994) Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science 265, 528. Kawabe, Y. & Yoshi, A. (1991) Programmed cell death and extrathymic reduction of Vβ8+ CD4+ T cells in mice tolerant to staphylococcus aureus enterotoxin B. Nature 349, 245. Kearney, E. R., Pape, K. A., Loh, D. Y. & Jenkins M. K. (1994) Visualization of peptide-specific T-cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327. Kerr, J. F. R., Willie, A. H. & Currie, A. R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239. Kestler, H., Kodama, T, Ringler, D., Marthas, M., Pedersen, N., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N. & Desrosiers, R. (1990) Induction of AIDS in rhesus monkeys by molecularly cloned SIV Science 148, 1109. Klas, C, Debatin, K. M., Jonker, R. R. & Krammer, P. H. (1993) Activation interferes with the APO-1 pathway in mature human T cells. International Immunology 5, 625. Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C, Perzeshkpour, G. H., Yungbluth, M., Janotta, F, Aksamit, A., Martin, M. A. & Fauci, A. S. (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233, 1089. Korsmeyer, S. (1992) Bcl-2: a repressor of lymphocyte death. Immunol. Today 13, 285. Kotler, D. P, Weaver, S. C. & Terzakis, J. A. (1986) Ultrastructural features of epithelial cell degeneration in rectal crypts of patients with AIDS. Am. J. Surg. Pathol. 10, 531. Kullberg, M. C, Pearce, E. J., Hieny, S. E., Sher, A. & Berzofsky, J. A. (1992) Infection with Schistosoma mansoni alters TH1/TH2 cytokine responses to a non-parasite antigen. J. Immunol. 148, 3264. Lackner, A. A., Vogel, P, Hoogenboom, E., Luge, J. D. & Marthas, M. (1994) Pathogenic (SIVmac-239) and nonpathogenic (SIVmac-lAll) molecular clones of SIV have distinct tissue distributions that vary with length of infection. In: Retroviruses of Human AIDS and Related Animal Diseases (VIII Colloque des Cent Gardes, 1993), eds. M. Girard & L. Valette M. Fondation, Lyon. p. 27. Lane, H. C, Depper, J. M., Greene, W. C, Whalen, G., Waldmann, T. A. & Fauci, A. S. (1985) Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. N. Engl, J. Med. 313, 79. Laurent-Crawford, A. G., Krust, B., Muller, S., Rivière, Y, Rey-Cuillé, M. A., Bechet, J. M., Montagnier, L. & Hovanessian, A. G. (1991) The cytopathic effect of HIV is associated with apoptosis. Virology 185, 829. Laurent-Crawford, A. G., Krust, B., Rivière, Y., Desganges, C, Muller, S., Kieny, M. P., Dauguet, C. & Hovanessian, A. G. (1993) Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res. Hum. Retrovir. 9, 761. Lenardo, M. J. (1991) IL-2 programs mouse αβ T-lymphocytes for apoptosis. Nature 353, 858. Levine, B., Huang, Q., Isaacs, J., Reed, J., Griffin, D. & Hardwick, J. (1993) Conversion of lytic to persistent alphavirus infection by the bcl-2 oncogene. Nature 361, 739. Levy, J. A. (1993a) HIV pathogenesis and long-term survival. AIDS 1, 1401. Levy, J. A. (1993b) Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 51, 183. Lewis, D. E., Ng Tang, D. S., Adu-Oppong, A., Schober, W. & Rodgers, J. R. (1994) Anergy and apoptosis in CD8+ T cells from HIV-infected persons. J. Immunol. 153, 412. Liu, Y. & Janeway, C. A. (1990) IFNy plays a crucial role in induced cell death of effector T cell; a possible third mechanism of self tolerance. J. Exp. Med. 111, 1735. Maggi, E., Mazzettin, M., Ravina, A., Annunziato, F, De Carli, M., Piccinni, M. P, Manetti, R., Carbonari, M., Pesce, A. M., Del Prete, G. & Romagnani, S. (1994) Ability of HIV to promote a THl to THO shift and to replicate preferentially in TH2 and THO cells. Science 265, 244. Mannhalter, J. W, Husch, B., Kupcu, Z. & Eibl, M. M. (1994) Capacity of HIV-1 to infect chimpanzee monocyte in vitro. J. Infect. Dis. 169, 1407. Marrack, P, Hugo, P, McCormack, J. & Kappler, J. (1993) Death and T cells. Immmological Reviews 133, 119. Marrack, P & Kappler, J. (1990) The staphylococcal enterotoxins and their relatives. Science 248, 705. Marrack, P. & Kappler, J. (1994) Subversion of the Immune system by pathogens. Cell 76, 323. Martin, S. J., Matear, P & Vyakarnam, A. (1994) HIV-1 infection of human CD4 T cells in vitro. Differential induction of apoptosis in these cells. J. Immunol. 152, 330. McConkey, D. J., Orrenius, S. & Jondal, M. (1990) Cellular signaling in programmed cell death (apoptosis). Immunol. Today 11, 120. McCormack, J. E., Callahan, J. E. Kappler, J. & Marrack, P. C. (1993) Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150, 3785. Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, I. P M. & Miedema, F (1992) Programmed cell death of T cells in HIV-1 infection. Science 257, 217. Meyaard, L., Otto, S. A., Keet, I. P M., Roos, M. T. L. & Miedema, F (1994) Programmed cell death of T cells in HIV infection. No correlation with progression to disease. J. Clin. Invest. 93, 982. Meyaard, L., Otto, S. A., Schuitemaker, H. & Miedema, F. (1993) T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function Immunol. Today. 14, 161. Michaels, I, Sharer, L. R. & Epstein, L. G. (1988) HlV-1 infection of the nervous system: a review. Immunodeficiency Rev. 1, 71. Miedema, F, Petit, A. J. C, Terpestra, F. G., Eeftinck Schattenkerk, J. K. M., Dewolf, F, Al, B. J. M., Roos, M., Lange, J. M. A., Danner, S. A., Goudsmit, J. & Schellekens, P. T.A. (1988) Immunological abnormalities in HIV-infected asymptomatic homosexual men. J. Clin. Invest. 82, 1908. Miyawaki, T, Uehara, T, Nibu, R., Tsuji, T, Yachie, A., Yonehara, S. & Taniguchi, N. (1992) Differential expression of apoptosis-related Fas antigen on lymphocyte sub-populations in human peripheral blood. J. Immunol 149, 3753. Moore, K. J. & Matlashewski, G. (1994) Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J. Immunol. 152, 2930. Mosier, D. & Sieburg, H. (1994) Macrophage-tropic HIV: critical for AIDS pathogenesis Immunol. Today 15, 332. Mosier, D. E., Gulizia, R. J., Maclsaac, P. D., Torbett, B. E. & Levy, J. A. (1993) Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260, 689. Moskophidis, D., Lechner, F, Pircher, H. & Zinkernagel, R. M. (1993) Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362, 758. Mosmann, T. R., Schumacher, J. H., Street, N. F, Budd R., O'Garra, A., Fong, T. A. T, Bond, M. W., Moore, K. W. M., Sher, A. & Fiorentino, D. F (1991) Diversity of cytokine synthesis and function of mouse CD4 T cells. Immunological Reviews 123, 209. Müller, M. C, Saksena, N. K., Nerrienet, E., Chappey, C, Herve, V. M. A., Durand, J. P, Legal-Campodonico, P., Lang, M. C, Digoutte, J. P., Georges, A. G., Georges-Courbot, M. C, Sonigo, P. & Barre-Sinoussi, F. (1993) Simian immunodeficiency viruses from Central and Western

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