Cytokine regulation by virus infection: bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro
1996; American Society for Microbiology; Volume: 70; Issue: 4 Linguagem: Inglês
10.1128/jvi.70.4.2650-2653.1996
ISSN1098-5514
AutoresHeiko Adler, T.W. Jungi, H Pfister, Marc Strasser, Maarten Sileghem, Ernst Peterhans,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoBovine bone marrow-derived macrophages were infected in vitro with noncytopathic or cytopathic strains of bovine viral diarrhea virus. Infection with both biotypes resulted in a decreased production of tumor necrosis factor alpha upon stimulation with heat-inactivated Salmonella dublin or lipopolysaccharide. Other macrophage functions were not downregulated, indicating that the observed effect was not due to a loss in macrophage viability. The downregulated production of tumor necrosis factor alpha in infected macrophages may contribute to the well-documented immunosuppression in animals infected with bovine viral diarrhea virus.
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