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BIBTEX RIS

Modulation of the CD8 + -T-Cell Response by CD4 + CD25 + Regulatory T Cells in Patients with Hepatitis B Virus Infection

2005; American Society for Microbiology; Volume: 79; Issue: 6 Linguagem: Inglês

10.1128/jvi.79.6.3322-3328.2005

ISSN

1098-5514

Autores

Ornella Franzese, Patrick Kennedy, Adam J. Gehring, Jim Gotto, Roger Williams, Mala K. Maini, Antonio Bertoletti,

Tópico(s)

Immune Cell Function and Interaction

Resumo

ABSTRACT CD4 + CD25 + regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4 + CD25 + T cells on CD8 + -T-cell responses of patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4 + CD25 + T cells modulate the function and expansion of HBV-specific CD8 + cells ex vivo in all patients, regardless of whether they have chronic or resolved HBV infection. The possible role of CD4 + CD25 + T cells in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have implications for optimizing future immunotherapeutic approaches to HBV treatment.

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