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The Role of Shugoshin in Meiotic Chromosome Segregation

2011; Karger Publishers; Volume: 133; Issue: 2-4 Linguagem: Inglês

10.1159/000323793

1424-8581

Dean Clift, Adèle L. Marston,

Ubiquitin and proteasome pathways

During meiosis, DNA replication is followed by 2 successive chromosome segregation events, resulting in the production of gametes with a haploid number of chromosomes from a diploid precursor cell. Faithful chromosome segregation in meiosis requires that sister chromatid cohesion is lost from chromosome arms during meiosis I, but retained at centromeric regions until meiosis II. Recent studies have begun to uncover the mechanisms underlying this stepwise loss of cohesion in meiosis and the role of a conserved protein, shugoshin, in regulating this process.