Uridine Receptor: Discovery and Its Involvement in Sleep Mechanism
2001; Oxford University Press; Volume: 24; Issue: 3 Linguagem: Inglês
10.1093/sleep/24.3.251
ISSN1550-9109
AutoresToshiyuki Kimura, Ing K. Ho, Ikuo Yamamoto,
Tópico(s)Pharmacological Receptor Mechanisms and Effects
ResumoThis review deals with the concept of sleep mechanism based on our uridine receptor theory. It is well established that uridine is one of the sleep-promoting substances, we have, therefore, synthesized new types of hypnotic compounds from oxopyrimidine nucleosides. Their mechanism of action in CNS depressant effects is elucidated based on the receptor theory. In this study, structure-activity relationship for CNS depressant properties, sleep-promoting effects, interaction with certain CNS receptors, and receptor binding assay of uridine derivatives as oxopyrimidine nucleoside were investigated.
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