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Iron Chloride/4‐Acetamido‐TEMPO/Sodium Nitrite‐Catalyzed Aerobic Oxidation of Primary Alcohols to the Aldehydes

2009; Wiley; Volume: 352; Issue: 1 Linguagem: Inglês

10.1002/adsc.200900662

1615-4169

Weili Yin, Changhu Chu, Qiongqiong Lu, Jianwei Tao, Xinmiao Liang, Renhua Liu,

Vanadium and Halogenation Chemistry

Abstract A variety of 4‐substituted 2,2,6,6‐tetramethylpiperidyl‐1‐oxy (TEMPO) derivatives has been screened for their ability in the oxidation of primary alcohols to the aldehydes with dioxygen under mild conditions. An evaluation of the efficiency of these 4‐substituted TEMPO derivatives in the alcohol oxidation may allow an insight into the effect of the structural variations of TEMPO on the oxidation of alcohols, which should facilitate catalyst design and screening efforts. Based on the screening results of 4‐substituted TEMPO derivatives, the catalyst comprised of 4‐acetamido‐TEMPO, iron chloride and sodium nitrite, has been developed for the highly efficient oxidation of a wide range of primary alcohols including primary aliphatic alcohols to the corresponding aldehydes under mild conditions.