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Hemodynamic effects of local anesthetics intoxication: experimental study in swine with levobupivacaine and bupivacaine

2008; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 23; Issue: 1 Linguagem: Inglês

10.1590/s0102-86502008000100010

1678-2674

Artur Udelsmann, Sílvia Elaine Rodolfo de Sá Lorena, Samira Ubaid Girioli, William Adalberto Silva, Ana Cristina de Moraes, Nelson Adami Andreollo,

Veterinary Pharmacology and Anesthesia

PURPOSE: To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines. Methods: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus injection of 4 mg/kg of either agent for intoxication. Hemodynamic results were then evaluated at 1, 5, 10, 15, 20 and 30 minutes. RESULTS: Levobupivacaine had greater hemodynamic repercussions than racemic bupivacaine. These results disagree with those found when the levorotatory isomer of bupivacaine was used in humans, but are in agreement with recently reported findings in animals. CONCLUSION: Levobupivacaine was shown to be more toxic in pigs than racemic bupivacaine when large doses are injected intravenously.