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CENTRAL N-ACETYLCYSTEINE EFFECTS ON BAROREFLEX IN JUVENILE SPONTANEOUSLY HYPERTENSIVE RATS

2011; Imperial College Press; Volume: 10; Issue: 02 Linguagem: Inglês

10.1142/s0219635211002671

1757-448X

Vítor Engrácia Valenti, Luíz Carlos de Abreu, Mônica Akemi Sato, Paulo Hilário Nascimento Saldiva, Fernando Luiz Affonso Fonseca, Gisele Giannocco, Andreas R P Riera, Celso Ferreira,

Neurological Disorders and Treatments

Journal of Integrative NeuroscienceVol. 10, No. 02, pp. 161-176 (2011) No AccessCENTRAL N-ACETYLCYSTEINE EFFECTS ON BAROREFLEX IN JUVENILE SPONTANEOUSLY HYPERTENSIVE RATSVITOR E. VALENTI, LUIZ CARLOS DE ABREU, MONICA A. SATO, PAULO H. N. SALDIVA, FERNANDO L. A. FONSECA, GISELE GIANNOCCO, ANDREAS R. P. RIERA, and CELSO FERREIRAVITOR E. VALENTIDepartamento de Medicina, Disciplina de Cardiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrazilDepartamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo SP, BrazilDepartamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, BrazilCorresponding author. Search for more papers by this author , LUIZ CARLOS DE ABREUDepartamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brazil Search for more papers by this author , MONICA A. SATODepartamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brazil Search for more papers by this author , PAULO H. N. SALDIVADepartamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo SP, Brazil Search for more papers by this author , FERNANDO L. A. FONSECADepartamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brazil Search for more papers by this author , GISELE GIANNOCCODepartamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brazil Search for more papers by this author , ANDREAS R. P. RIERADepartamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brazil Search for more papers by this author , and CELSO FERREIRADepartamento de Medicina, Disciplina de Cardiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil Search for more papers by this author https://doi.org/10.1142/S0219635211002671Cited by:5 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractIn this study, we evaluated the acute effects of central NAC administration on baroreflex in juvenile SHR and Wistar Kyoto (WKY) rats. Male SHR and WKY rats (8–10 weeks old) were implanted with a stainless steel guide cannula into the fourth cerebral ventricle (4th V). The femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. After basal MAP and HR recordings, the baroreflex was tested with a pressor dose of phenylephrine (PHE, 8 μg/kg, bolus) and a depressor dose of sodium nitroprusside (SNP, 50 μg/kg, bolus). Baroreflex was evaluated before, 5, 15, 30 and 60 minutes after NAC injection into the 4th V. Vehicle treatment did not change baroreflex responses in WKY and SHR. Central NAC slightly but significantly increased basal HR at 15 minutes and significantly reduced PHE-induced increase in MAP 30 and 60 minutes after NAC injection (p < 0.05) in WKY rats. In relation to SHR, NAC decreased HR range 15 and 30 minutes after its administration. In conclusion, acute NAC into the 4th V does not improve baroreflex in juvenile SHR.Keywords:Baroreflexacetylcysteinerats, inbred SHRoxidative stress References O. I. Aruomaet al., Free. Radic. Biol. Med. 6, 593 (1989). Crossref, Medline, ISI, Google ScholarM. A. Ersoyet al., Int. J. Neurosci. 118, 1025 (2008). Crossref, Medline, ISI, Google ScholarM. Akay, K. L. 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Rodrigues, and Luiz Carlos De Abreu30 April 2012 | Journal of Integrative Neuroscience, Vol. 10, No. 04 Recommended Vol. 10, No. 02 Metrics History Received 12 March 2011 Accepted 28 April 2011 KeywordsBaroreflexacetylcysteinerats, inbred SHRoxidative stressPDF download