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Temporary dermal scatter reduction: Quantitative assessment and implications for improved laser tattoo removal

2005; Wiley; Volume: 36; Issue: 4 Linguagem: Inglês

10.1002/lsm.20152

1096-9101

Roger J. McNichols, Matthew A. Fox, Ashok Gowda, Tuya Shilagard, Brent A. Bell, Massoud Motamedi,

Laser Applications in Dentistry and Medicine

Lasers in Surgery and MedicineVolume 36, Issue 4 p. 289-296 Research Article Temporary dermal scatter reduction: Quantitative assessment and implications for improved laser tattoo removal† Roger J. McNichols, Corresponding Author Roger J. McNichols roger@biotexmedical.com BioTex, Inc., Houston, Texas 77054BioTex, Inc., 8058 El. Rio Street, Houston, TX 77054.Search for more papers by this authorMatthew A. Fox, Matthew A. Fox BioTex, Inc., Houston, Texas 77054Search for more papers by this authorAshok Gowda, Ashok Gowda BioTex, Inc., Houston, Texas 77054Search for more papers by this authorShilagard Tuya, Shilagard Tuya Biomedical Engineering Center, University of Texas Medical Branch, Galveston, Texas 77555Search for more papers by this authorBrent Bell, Brent Bell Biomedical Engineering Center, University of Texas Medical Branch, Galveston, Texas 77555Search for more papers by this authorMassoud Motamedi, Massoud Motamedi Biomedical Engineering Center, University of Texas Medical Branch, Galveston, Texas 77555Search for more papers by this author Roger J. McNichols, Corresponding Author Roger J. McNichols roger@biotexmedical.com BioTex, Inc., Houston, Texas 77054BioTex, Inc., 8058 El. Rio Street, Houston, TX 77054.Search for more papers by this authorMatthew A. Fox, Matthew A. Fox BioTex, Inc., Houston, Texas 77054Search for more papers by this authorAshok Gowda, Ashok Gowda BioTex, Inc., Houston, Texas 77054Search for more papers by this authorShilagard Tuya, Shilagard Tuya Biomedical Engineering Center, University of Texas Medical Branch, Galveston, Texas 77555Search for more papers by this authorBrent Bell, Brent Bell Biomedical Engineering Center, University of Texas Medical Branch, Galveston, Texas 77555Search for more papers by this authorMassoud Motamedi, Massoud Motamedi Biomedical Engineering Center, University of Texas Medical Branch, Galveston, Texas 77555Search for more papers by this author First published: 11 April 2005 https://doi.org/10.1002/lsm.20152Citations: 50 † R.J.M., M.A.F., and A.G. have disclosed potential financial conflicts of interest with this study. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background and Objectives Temporary dermal clearing, i.e., reduction in the attenuation coefficient of the dermis and epidermis, may lead to improved laser tattoo removal by providing increased efficiency of laser delivery to embedded ink particles and enabling the use of shorter wavelength visible lasers more effective on certain inks. Study Designs/Materials and Methods In a hairless guinea pig model of human tattoo, we tested both intradermal and transdermal application of glycerol, using visual inspection, spectral analysis, and optical coherence tomography techniques to assess effectiveness. In controlled experiments, we compared the outcomes of single laser treatment sessions for both cleared and uncleared tattoo sites using Q-switched 755 and 532 nm lasers on three different inks. Results Intradermal injection of clearing agents induced dermal clearing but resulted in necrosis and scar. Transdermal application of clearing agents resulted in moderate reversible clearing, which was localized to the superficial layers of the skin and did not result in complications. Statistically significant differences in laser treatment outcome were observed relative to a number of treatment parameters including the treatment of certain tattoos by short wavelength lasers. Conclusions Temporary clearing of superficial skin layers may be performed in an apparently safe and reliable manner. Clearing should lead to increased penetration of laser light to tattoos and should, therefore, increase treatment efficiency. Further study is needed to determine the degree to which this change is of clinical value. Lasers Surg. Med. 36:289–296, 2005. © 2005 Wiley-Liss, Inc. Citing Literature Volume36, Issue4April 2005Pages 289-296 RelatedInformation