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BIBTEX RIS

Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

2011; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 8 Linguagem: Inglês

10.3390/molecules16087125

ISSN

1433-1373

Autores

Ana Sílvia Suassuna Carneiro Lúcio, Jackson Roberto Guedes da Silva Almeida, José Maria Barbosa‐Filho, João Carlos Lima Rodrigues Pita, Marianna Vieira Sobral Castello Branco, Margareth de Fátima Formiga Melo Diniz, Maria de Fátima Agra, Emídio Vasconcelos Leitão da Cunha, Marcelo Sobral da Silva, Josean Fechine Tavares,

Tópico(s)

Piperaceae Chemical and Biological Studies

Resumo

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively.

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