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Cervical Human Immunodeficiency Virus Type 1 Shedding Is Associated with Genital β‐Chemokine Secretion

1998; Oxford University Press; Volume: 178; Issue: 5 Linguagem: Inglês

10.1086/314433

1537-6613

Astrid K. N. Iversen, Lars Fugger, Jesper Eugen‐Olsen, Ulla Balslev, Trine Hammer Jensen, Susanne Wahl, Jan Gerstoft, James I. Mullins, Peter Skinhøj,

Immune Cell Function and Interaction

Forty human immunodeficiency virus type 1 (HIV-1)—infected women participated in a cross-sectional study of possible correlations between chemokine receptor (CCR5 and/or CCR2B) genotype, HIV-1 RNA and DNA load, and β-chemokine levels (RANTES, MIP-1a, MIP-1β) in blood and cervix. HIV-1 nucleic acid and β-chemokines were found in all patient blood samples and in more than half of the cervical samples regardless of CCR5 or CCR2B genotype. High β-chemokine concentrations were in general associated with high virus loads in blood and cervix. In the blood, the proviral DNA load was significantly correlated with the MIP-1a concentration, whereas the DNA load in cervix was significantly associated with the MIP-1β concentration. The cervical viral RNA load was significantly associated with levels of all three chemokines. Thus, when HIV-1 shedding was highest in the genital tract, it was associated with other combinations of β-chemokines than virus load in blood, suggesting that local immune reactions strongly influence virus load in the cervical compartment.