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BIBTEX RIS

Antifungal susceptibility of 1000 Candida bloodstream isolates to 5 antifungal drugs: results of a multicenter study conducted in São Paulo, Brazil, 1995–2003

2007; Elsevier BV; Volume: 57; Issue: 4 Linguagem: Inglês

10.1016/j.diagmicrobio.2006.10.011

1879-0070

Daniel Archimedes da Matta, Leila Paula de Almeida, Antônia Maria de Oliveira Machado, Ana Carolina Azevedo, Elisa Junko Ura Kusano, Norma Fracalanza Travassos, Reinaldo Salomão, Arnaldo Lopes Colombo,

Pneumocystis jirovecii pneumonia detection and treatment

We evaluated all Candida sp. bloodstream isolates obtained from patients admitted to 4 tertiary care hospitals between 1995 and 2003 in the city of São Paulo, Brazil. Susceptibility to amphotericin B, 5-fluorocytosine, fluconazole (FCZ), itraconazole (ITZ), and voriconazole (VCZ) was determined using the Clinical Laboratory Standards Institute broth microdilution method. We tested a total of 1000 strains, including 400 strains of Candida albicans (40%), 243 of Candida tropicalis (24.3%), 238 of Candida parapsilosis (23.8%), 44 of C. glabrata (4.4%), 30 of Candida guilliermondii (3%), and 25 of Candida rugosa (2.5%). Only 1.9% of the strains tested were susceptible in a dose-dependent manner, and 0.2% of them were resistant to FCZ. Almost 100% of the strains were susceptible to VCZ. Despite that azole resistance was a rare finding, a trend toward increased resistance among C. rugosa strains to FCZ and ITZ was noted.