The Putative Glycosyltransferase-Encoding Gene cylJ and the Group B Streptococcus (GBS)-Specific Gene cylK Modulate Hemolysin Production and Virulence of GBS

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The Putative Glycosyltransferase-Encoding Gene cylJ and the Group B Streptococcus (GBS)-Specific Gene cylK Modulate Hemolysin Production and Virulence of GBS

2007; American Society for Microbiology; Volume: 75; Issue: 4 Linguagem: Inglês

10.1128/iai.01565-06

ISSN

1098-5522

Autores

Marie-Pierre Forquin, Asmaa Tazi, Manuel Rosa-Fraile, Claire Poyart, Patrick Trieu‐Cuot, Shaynoor Dramsi,

Tópico(s)

Antimicrobial Resistance in Staphylococcus

Resumo

Group B streptococcus (GBS) expresses a hemolysin/cytolysin that plays an important role in pathogenesis. Using the Himar1 transposon mutagenesis system, a hypohemolytic mutant carrying an interrupted cylJ gene was characterized. cylJ, encoding a putative glycosyltransferase, and cylK, whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS.

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The Putative Glycosyltransferase-Encoding Gene cylJ and the Group B Streptococcus (GBS)-Specific Gene cylK Modulate Hemolysin Production and Virulence of GBS