The Changing Face of HIV/AIDS in Treated Patients
2009; Bentham Science Publishers; Volume: 7; Issue: 4 Linguagem: Inglês
10.2174/157016209788680633
ISSN1873-4251
AutoresJosep M. Llibre, Vicenç Falcó, Cristina Tural, Eugènia Negredo, Juan A. Pineda, José F. Muñoz, Enrique Ortega, Sebastián Videla, Guillem Sirera, Estebán Martínez, Celia Miralles, Josean Iribarren, María Galindo, Peré Domingo, Antonella d'Arminio-Monforte, José M. Miró, Bonaventura Clotet,
Tópico(s)Neurological Complications and Syndromes
ResumoThe spectrum of complications emerging in successfully treated HIV-infected patients has dramatically changed since the advent of HAART. Typical AIDS-defining illnesses have been substituted by new comorbid conditions that threaten even those patients who maintain virologic suppression. Proper management of cardiovascular risk, and early diagnosis of AIDS-related and, particularly, non-AIDS-related malignancies (including papilomavirus-related neoplasms) must be introduced into the routine of care. Hot areas of investigation include HIV-associated neurocognitive disorders, hepatitis B and C coinfection, non-alcoholic fatty liver disease, progressive multifocal leukoencephalopathy and tuberculosis. Bone and kidney long-term toxicities and lipoatrophy remain as issues of paramount importance. The identification and early treatment of immune reconstitution disease is also of major interest, specially in those patients starting their antiretroviral treatment with severe CD4 cell depletion. The present review focuses on these twelve areas of increasing interest for physicians currently facing successfully treated HIV+ patients. Keywords: AIDS, papillomavirus, hepatitis, progressive multifocal leukoencephalopathy, neoplasia, immune reconstitution syndrome, AIDS dementia complex, cardiovascular disease
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