PD-1– and CTLA-4–Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses

Artigo Acesso aberto Revisado por pares

2013; American Association for the Advancement of Science; Volume: 5; Issue: 215 Linguagem: Inglês

10.1126/scitranslmed.3006597

ISSN

1946-6242

Autores

V D Fedorov, Maria Themeli, Michel Sadelain,

Tópico(s)

Immune Cell Function and Interaction

Resumo

Human T cells that are reversibly inhibited upon contact with antigen protect bystander tissues from immune destruction.

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