Potassium N ‐Iodo p ‐Toluenesulfonamide (TsNIK, Iodamine‐T): A New Reagent for the Oxidation of Hydrazones to Diazo Compounds
2014; Wiley; Volume: 20; Issue: 15 Linguagem: Inglês
10.1002/chem.201304656
ISSN1521-3765
AutoresSimon M. Nicolle, Christopher J. Moody,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoAbstract A new reagent for the oxidation of hydrazones to diazo compounds is described. N ‐Iodo p ‐toluenesulfonamide (TsNIK, iodamine‐T) allows the preparation of α‐diazoesters, α‐diazoamides, α‐diazoketones and α‐diazophosphonates in good yield and in high purity after a simple extractive work‐up. α‐Diazoesters were also obtained in high yield from the corresponding ketones through a one‐pot process of hydrazone formation/oxidation.
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