Effect of Ribavirin and Glucocorticoid Treatment in a Mouse Model of Human Metapneumovirus Infection
2006; American Society for Microbiology; Volume: 50; Issue: 2 Linguagem: Inglês
10.1128/aac.50.2.774-777.2006
ISSN1098-6596
AutoresMarie‐Ève Hamelin, Gregory A. Prince, Guy Boivin,
Tópico(s)Viral Infections and Immunology Research
ResumoABSTRACT Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log 10 ) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.
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