Produção Nacional
Revisado por pares
Procalcitonin and C-reactive protein kinetics in postoperative pediatric cardiac surgical patients
2004; Elsevier BV; Volume: 18; Issue: 2 Linguagem: Inglês
10.1053/j.jvca.2004.01.021
ISSN1532-8422
AutoresRonaldo Arkader, Eduardo Juan Troster, Deipara Monteiro Abellan, Marcel Rezende Lopes, Roberto Raiz Júnior, Joseph A. Carcillo, Thelma Suely Okay,
Tópico(s)Hemodynamic Monitoring and Therapy
ResumoTo determine the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) concentration after pediatric cardiac surgery with cardiopulmonary bypass.Prospective, clinical cohort study.A fifteen-bed tertiary-care pediatric intensive care unit.Fourteen pediatric patients admitted for cardiac surgery.Serum PCT and CRP were measured before cardiopulmonary bypass (CPB); after CPB; and on the first, second, and third days after surgery by means of immunoluminometry and nephelometry, respectively. Reference values for systemic inflammatory response syndrome are 0.5 to 2.0 ng/mL for PCT and <5 mg/L for CRP. Baseline serum PCT and CRP concentrations were 0.24 +/- 0.13 ng/mL and 4.06 +/- 3.60 mg/L (median 25th percentile-75th percentile), respectively. PCT concentrations increased progressively from the end of CPB (0.62 +/- 0.30 ng/mL), peaked at 24 hours postoperatively (POD1) (0.77 +/- 0.49 ng/mL), and began to decrease at 48 hours or POD2 (0.35 +/- 0.21 ng/mL). CRP increased just after CPB (58.82 +/- 42.23 mg/L) and decreased after 72 hours (7.09 +/- 9.81 mg/L).An increment of both PCT and CRP was observed just after CPB. However, PCT values remained within reference values, whereas CRP concentrations increased significantly after CPB until the third day. These preliminary results suggest that PCT was more effective than CRP to monitor patients with SIRS and a favorable outcome.
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