Intravesical Capsaicin for Treatment of Severe Bladder Pain: A Randomized Placebo Controlled Study
1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 3 Linguagem: Inglês
10.1016/s0022-5347(01)65669-6
ISSN1527-3792
AutoresMassimo Lazzeri, Patrizia Beneforti, G. Benaim, C.A. Maggi, Alessandro Lecci, Damiano Turini,
Tópico(s)Ion Channels and Receptors
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Sep 1996Intravesical Capsaicin for Treatment of Severe Bladder Pain: A Randomized Placebo Controlled Study M. Lazzeri, P. Beneforti, G. Benaim, C.A. Maggi, A. Lecci, and D. Turini M. LazzeriM. Lazzeri , P. BenefortiP. Beneforti , G. BenaimG. Benaim , C.A. MaggiC.A. Maggi , A. LecciA. Lecci , and D. TuriniD. Turini View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65669-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Present therapeutic approaches to control bladder pain are clinically and scientifically unsatisfactory, and pain in the lower urinary tract remains a challenge even to the skilled urologist. A randomized placebo controlled study was done to evaluate intravesical capsaicin for severe bladder pain. Followup was 6 months. Materials and Methods: A total of 36 patients was prospectively randomized into those receiving 10 micromolar intravesical capsaicin twice weekly for 1 month (group 1) or placebo (group 2). All patients had pelvic pain for at least 6 months, and had no urinary tract infection within the last 3 months, functional disorders of the lower urinary tract, or other vesical or urethral pathology. Pretreatment voiding pattern and pain score were recorded. Patients were evaluated immediately at the end of treatment (primary end point) and 6 months later (secondary end point). Results: Both groups were adequately homogenous with regard to age, sex ratio, duration of disease, voiding pattern and pain score. At both end points group 1 had significant improvement in frequency and nocturia but no improvement in urgency. No change was noted in group 2. A significant decrease in pain score was found in group 1 at the primary (mean plus or minus standard deviation 3.22 plus/minus 0.42, p less than 0.01) and secondary (3.83 plus/minus 0.47, p less than 0.01) end points compared to before treatment (5.61 plus/minus 0.40, chi-square with 2 degrees of freedom 29.25, p less than 0.0001). A significant improvement was also observed in the placebo group, in which the pretreatment pain score (5.47 plus/minus 0.37) was decreased at the primary (4.47 plus/minus 0.36, p less than 0.01) and secondary (4.48 plus/minus 0.34, p less than 0.01, chi-square with 2 degrees of freedom 12.71, p less than 0.002) end points. There were no statistically significant differences between the 2 groups. Conclusions: We confirmed the beneficial effect of intravesical instillation of capsaicin on voiding pattern in patients with hypersensitive disorders (frequency and nocturia). 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Google Scholar From the Department of Urology, University of Ferrara, and Department of Pharmacology, "A Menarini" Institute, Florence, Italy.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPAYNE C, MOSBAUGH P, FORREST J, EVANS R, WHITMORE K, ANTOCI J, PEREZ-MARRERO R, JACOBY K, DIOKNO A, O'REILLY K, GRIEBLING T, VASAVADA S, YU A and FRUMKIN L (2018) INTRAVESICAL RESINIFERATOXIN FOR THE TREATMENT OF INTERSTITIAL CYSTITIS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIALJournal of Urology, VOL. 173, NO. 5, (1590-1594), Online publication date: 1-May-2005.KUO H (2018) Effectiveness Of Intravesical Resiniferatoxin For Anticholinergic Treatment Refractory Detrusor Overactivity Due To Nonspinal Cord LesionsJournal of Urology, VOL. 170, NO. 3, (835-839), Online publication date: 1-Sep-2003.LAZZERI M, BENEFORTI P, SPINELLI M, ZANOLLO A, BARBAGLI G and TURINI D (2018) INTRAVESICAL RESINIFERATOXIN FOR THE TREATMENT OF HYPERSENSITIVE DISORDER: A RANDOMIZED PLACEBO CONTROLLED STUDYJournal of Urology, VOL. 164, NO. 3 Part 1, (676-679), Online publication date: 1-Sep-2000.CHANCELLOR M and de GROAT W (2018) INTRAVESICAL CAPSAICIN AND RESINIFERATOXIN THERAPY: SPICING UP THE WAYS TO TREAT THE OVERACTIVE BLADDERJournal of Urology, VOL. 162, NO. 1, (3-11), Online publication date: 1-Jul-1999.DASGUPTA P, FOWLER C and STEPHEN R (2018) ELECTROMOTIVE DRUG ADMINISTRATION OF LIDOCAINE TO ANESTHETIZE THE BLADDER BEFORE INTRAVESICAL CAPSAICINJournal of Urology, VOL. 159, NO. 6, (1857-1861), Online publication date: 1-Jun-1998.De Ridder D, Chandiramani V, Dasgupta P, Van Popple H, Baert L and Fowler C (2018) INTRAVESICAL CAPSAICIN AS A TREATMENT FOR REFRACTORY DETRUSOR HYPERREFLEXIA: A DUAL CENTER STUDY WITH LONG-TERM FOLLOWUPJournal of Urology, VOL. 158, NO. 6, (2087-2092), Online publication date: 1-Dec-1997.Lazzeri M, Beneforti P and Turini D (2018) URODYNAMIC EFFECTS OF INTRAVESICAL RESINIFERATOXIN IN HUMANS: PRELIMINARY RESULTS IN STABLE AND UNSTABLE DETRUSORJournal of Urology, VOL. 158, NO. 6, (2093-2096), Online publication date: 1-Dec-1997. Volume 156Issue 3September 1996Page: 947-952 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information M. Lazzeri More articles by this author P. Beneforti More articles by this author G. Benaim More articles by this author C.A. Maggi More articles by this author A. Lecci More articles by this author D. Turini More articles by this author Expand All Advertisement PDF downloadLoading ...
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