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Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

2015; American Medical Association; Volume: 313; Issue: 19 Linguagem: Inglês

10.1001/jama.2015.4668

1538-3598

Willemijn J. Jansen, Rik Ossenkoppele, Dirk L. Knol, Betty M. Tijms, Philip Scheltens, Frans R.J. Verhey, Pieter Jelle Visser, Pauline Aalten, Dag Aarsland, Daniel Alcolea, M Alexander, Ina S. Almdahl, Steven E. Arnold, Inês Baldeiras, Henryk Barthel, Bart N.M. van Berckel, Kristen Bibeau, Kaj Blennow, David J. Brooks, Mark A. van Buchem, Vincent Camus, Enrica Cavedo, Kewei Chen, Gaël Chételat, Ann D. Cohen, Alexander Drzezga, Sebastiaan Engelborghs, Anne M. Fagan, Tormod Fladby, Adam Fleisher, Wiesje M. van der Flier, Lisa Ford, Stefan Förster, Juan Fortea, Nadia Foskett, Kristian Steen Frederiksen, Yvonne Freund‐Levi, Giovanni B. Frisoni, Lutz Froelich, Tomasz Gabryelewicz, Kiran Dip Gill, Olymbia Gkatzima, Estrella Gómez‐Tortosa, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna‐Kaisa Herukka, Helmut Hildebrandt, Lianna Ishihara, Adrian Ivanoiu, William J. Jagust, Peter Johannsen, Ramesh Kandimalla, Elisabeth Kapaki, Aleksandra Klimkowicz‐Mrowiec, William E. Klunk, Sebastian Köhler, Norman Koglin, Johannes Kornhuber, Milica G. Kramberger, Koen Van Laere, Susan Landau, Dong Young Lee, Mony J. de Leon, Viviana Lisetti, Alberto Lleó, Karine Madsen, Wolfgang Maier, Jan Marcusson, Niklas Mattsson, Alexandre de Mendonça, Olga Meulenbroek, Philipp T. Meyer, Mark A. Mintun, Vincent Mok, José Luís Molinuevo, Hanne M. Møllergård, John C. Morris, Barbara Mroczko, Stefan Van der Mussele, Duk L. Na, Andrew B. Newberg, Agneta Nordberg, Arto Nordlund, Gerald Novak, George P. Paraskevas, Lucilla Parnetti, Gayan Perera, Oliver Peters, Julius Popp, Sudesh Prabhakar, Gil D. Rabinovici, Inez H.G.B. Ramakers, Lorena Rami, Catarina R. Oliveira, Juha O. Rinne, Karen M. Rodrigue, Eloy Rodríguez‐Rodríguez, Catherine M. Roe, Uroš Rot, Christopher C. Rowe, Eckart Rüther, Osama Sabri, Pascual Sánchez‐Juan, Isabel Santana, Marie Sarazin, Johannes Schröder, Christin Schütte, Sang Won Seo, Femke Soetewey, Hilkka Soininen, Luiza Spiru, Hanne Struyfs, Charlotte E. Teunissen, Magda Tsolaki, Rik Vandenberghe, Marcel M. Verbeek, Victor L. Villemagne, Stephanie J. B. Vos, Linda J. C. van Waalwijk van Doorn, Gunhild Waldemar, Anders Wallin, Åsa K. Wallin, Jens Wiltfang, David A. Wolk, Marzena Zboch, Henrik Zetterberg,

Alzheimer's disease research and treatments

Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.