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Double-blind trial of cholestyramine in post-vagotomy diarrhoea.

1977; BMJ; Volume: 18; Issue: 7 Linguagem: Inglês

10.1136/gut.18.7.531

1468-3288

V. M. Duncombe, T. D. Bolin, A. E. Davis,

Clinical Nutrition and Gastroenterology

The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when compared with normal controls. These findings confirm the effectiveness of cholestyramine and support the concept of a bile acid mediated aetiology in post-vagotomy diarrhoea.