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Premature mortality in autism spectrum disorder

2015; Cambridge University Press; Volume: 208; Issue: 3 Linguagem: Inglês

10.1192/bjp.bp.114.160192

1472-1465

Tatja Hirvikoski, Ellenor Mittendorfer‐Rutz, Marcus Boman, Henrik Larsson, Paul Lichtenstein, Sven Bölte,

Child Nutrition and Feeding Issues

Background Mortality has been suggested to be increased in autism spectrum disorder (ASD). Aims To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability. Method Odds ratios (ORs) were calculated for a population-based cohort of ASD probands ( n = 27 122, diagnosed between 1987 and 2009) compared with gender-, age- and county of residence-matched controls ( n = 2 672 185). Results During the observed period, 24 358 (0.91%) individuals in the general population died, whereas the corresponding figure for individuals with ASD was 706 (2.60%; OR = 2.56; 95% CI 2.38–2.76). Cause-specific analyses showed elevated mortality in ASD for almost all analysed diagnostic categories. Mortality and patterns for cause-specific mortality were partly moderated by gender and general intellectual ability. Conclusions Premature mortality was markedly increased in ASD owing to a multitude of medical conditions.