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BIBTEX RIS

Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp.

2009; Brazilian Chemical Society; Volume: 20; Issue: 1 Linguagem: Inglês

10.1590/s0103-50532009000100029

ISSN

1678-4790

Autores

Michelle Verza, Nilton Syogo Arakawa, Norberto Peporine Lopes, Massuo J. Kato, Mônica Tallarico Pupo, Suraia Said, Ivone Carvalho,

Tópico(s)

Carbohydrate Chemistry and Synthesis

Resumo

The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 μmol L-1) similar to the natural precursor (IC50 3.7 μmol L-1).

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