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Oxidation of Guanine and 8‐oxo‐7,8‐Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen‐18 Labeling Experiments

2005; Wiley; Volume: 44; Issue: 32 Linguagem: Inglês

10.1002/anie.200500991

1521-3773

Conor Crean, Nicholas E. Geacintov, Vladimir Shafirovich,

CO2 Reduction Techniques and Catalysts

Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O− from CO3.− to the end products (see scheme).