Produção Nacional
Revisado por pares
Molecular detection ofChlamydia trachomatis and HPV infections in cervical samples with normal and abnormal cytopathological findings
2007; Wiley; Volume: 35; Issue: 4 Linguagem: Inglês
10.1002/dc.20629
ISSN8755-1039
AutoresFrancisco Danilo Ferreira Paula, Ana Paula Fernandes, Bianca Bianco do Carmo, Daniela Cristina Duarte Vieira, Míriam Santos Dutra, Caleb Guedes Miranda dos Santos, Maria do Carmo Souza, Túlio César Alvim Andrade, A Vágó, Paula Ávila Fernandes,
Tópico(s)Genital Health and Disease
ResumoAbstract It has been suggested that Chlamydia trachomatis (CT) and human papillomaviruses (HPV) co‐infection could contribute to development of intraepithelial lesions. In this study, HPV and CT‐DNA were investigated in 250 cervicovaginal samples of patients from Minas Gerais, Brazil. The cytological analysis revealed that 70% of samples (175) were negative, 5.2% (13) presented atypical squamous or glandular cells of undetermined significance (ASCUS/AGUS), 12.4% (31) presented low‐grade squamous intraepithelial lesion (LSIL), 10.8% (27) high‐grade squamous intraepithelial lesion (HSIL), and 1.6% (4) invasive carcinoma. HPV‐DNA and HPV/CT co‐infection was observed in 40% (100/250) and in 5.2% (13/250) of samples, respectively. Among the positive cytological samples, HPV‐DNA was detected in 73.3% and CT‐DNA in 9.33% and in 13%, if only the HPV positive samples were considered. The highest co‐infection rate (15.4%) was observed among ASCUS/AGUS samples. Although a significant association was found for HPV infection and the precursor lesions of cervical cancer, it was not possible to establish a significant association between these lesions and CT or HPV/CT co‐infection. Diagn. Cytopathol. 2007;35:198–202. © 2007 Wiley‐Liss, Inc.
Referência(s)