Premalignant Breast Neoplasia: A Paradigm of Interlesional and Intralesional Molecular Heterogeneity and Its Biological and Clinical Ramifications
2010; American Association for Cancer Research; Volume: 3; Issue: 5 Linguagem: Inglês
10.1158/1940-6207.capr-10-0073
ISSN1940-6207
AutoresHal K. Berman, Mona L. Gauthier, Thea D. Tlsty,
Tópico(s)Cancer-related Molecular Pathways
ResumoAs is well established in invasive breast disease, it is becoming increasingly clear that molecular heterogeneity, both between and within lesions, is a prevalent, distinct phenotype of premalignant lesions of the breast. Key pathways of tumorigenesis modulate critical features of premalignant lesions such as proliferation, differentiation, stress response, and even the generation of diversity. Current studies show that evaluation of these lesions may provide clinically useful information on future tumor formation as well as biological insights into the origin and functional significance of this distinct phenotype.
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