Revisão Acesso aberto Revisado por pares

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

2012; Cell Press; Volume: 21; Issue: 3 Linguagem: Inglês

10.1016/j.ccr.2012.02.022

ISSN

1878-3686

Autores

Douglas Hanahan, Lisa M. Coussens,

Tópico(s)

Cancer, Hypoxia, and Metabolism

Resumo

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.

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