Rare genetic variants previously associated with congenital forms of long QT syndrome have little or no effect on the QT interval
2015; Oxford University Press; Volume: 36; Issue: 37 Linguagem: Inglês
10.1093/eurheartj/ehv297
ISSN1522-9645
AutoresJonas Ghouse, Henri Theil, Peter Weeke, Jonas B. Nielsen, Gustav Ahlberg, Marie Balslev‐Harder, Emil V. R. Appel, Tea Skaaby, Søren‐Peter Olesen, Niels Grarup, Allan Linneberg, Oluf Pedersen, Stig Haunsø, Jesper Hastrup Svendsen, Torben Hansen, Jørgen K. Kanters, Morten S. Olesen,
Tópico(s)Ion channel regulation and function
ResumoAimsWe studied whether variants previously associated with congenital long QT syndrome (cLQTS) have an effect on the QTc interval in a Danish population sample. Furthermore, we assessed whether carriers of variants in cLQTS-associated genes are more prone to experience syncope compared with non-carriers and whether carriers have an increased mortality compared with non-carriers.
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