Produção Nacional
Revisado por pares
Elucidating the Neurotoxicity of the Star Fruit
2013; Wiley; Volume: 52; Issue: 49 Linguagem: Inglês
10.1002/anie.201305382
ISSN1521-3773
AutoresNorberto Garcia‐Cairasco, Miguel Moysés Neto, Flávio Del Vecchio, José Antônio Cortes de Oliveira, Francisco L. dos Santos, Olagide Wagner de Castro, Gabriel Maisonnave Arisi, Márcio Dantas, Ruither Oliveira Gomes Carolino, Joaquim Coutinho‐Netto, André Dagostin, M. Rodrigues, Ricardo M. Leão, Samir A. P. Quintiliano, Luiz F. Silva, Leonardo Gobbo‐Neto, Norberto Peporine Lopes,
Tópico(s)Bioactive natural compounds
ResumoCaramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.
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