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BIBTEX RIS

Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin

1999; American Society for Microbiology; Volume: 43; Issue: 4 Linguagem: Inglês

10.1128/aac.43.4.975

ISSN

1098-6596

Autores

Ian Wiid, Eileen G. Hoal, Dinie Hon, Carl Lombard, Paul D. van Helden,

Tópico(s)

Tryptophan and brain disorders

Resumo

The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.

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