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Preliminary Results of M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) for Transitional Cell Carcinoma of the Urothelium

1985; Lippincott Williams & Wilkins; Volume: 133; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(17)48996-8

1527-3792

Cora N. Sternberg, Alan Yagoda, Howard I. Scher, Robin C. Watson, Tauseef Ahmed, Lora Weiselberg, Nancy L. Geller, Phyllis Hollander, Harry W. Herr, Pramod C. Sogani, Michael J. Morse, Willet F. Whitmore,

Lymphoma Diagnosis and Treatment

No AccessJournal of Urology1 Mar 1985Preliminary Results of M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) for Transitional Cell Carcinoma of the Urothelium Cora N. Sternberg, Alan Yagoda, Howard I. Scher, Robin C. Watson, Tauseef Ahmed, Lora R. Weiselberg, Nancy Geller, Phyllis S. Hollander, Harry W. Herr, Pramod C. Sogani, Michael J. Morse, and Willet F. Whitmore Cora N. SternbergCora N. Sternberg , Alan YagodaAlan Yagoda , Howard I. ScherHoward I. Scher , Robin C. WatsonRobin C. Watson , Tauseef AhmedTauseef Ahmed , Lora R. WeiselbergLora R. Weiselberg , Nancy GellerNancy Geller , Phyllis S. HollanderPhyllis S. Hollander , Harry W. HerrHarry W. Herr , Pramod C. SoganiPramod C. Sogani , Michael J. MorseMichael J. Morse , and Willet F. WhitmoreWillet F. Whitmore View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)48996-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) regimen was used to treat 25 patients with transitional cell carcinoma of the urothelial tract. Treatment consisted of monthly cycles of 30mg. per m.2 methotrexate, followed 24 hours later by 3mg. per m.2 vinblastine, 30mg. per m.2 doxorubicin and 70mg. per m.2 cisplatin, and concluded with repeat vinblastine and methotrexate on days 15 and 22. Significant tumor regression was noted in 71 per cent of the patients. Complete clinical remission was observed in 12 of 24 patients (50 per cent, 95 per cent confidence limits 30 to 70 per cent) with bidimensionally measurable indicator lesions, 6 of whom had pathological confirmation. After surgical exploration 4 patients required downstaging to a partial remission. The median duration of response has not yet been reached at 9.5 plus months, range 4.5 plus to 16 plus. Five patients (21 per cent) had a partial clinical remission for 4 to 8 plus months, 1 had a minor response for 4 months and 1 had stable disease for 11 months. All metastatic sites responded, including bone (6 of 8 cases), liver (3 of 5), locoregional (12 of 17) and intravesical (6 of 7) disease. Toxicity included moderately severe myelosuppression that resulted in nadir sepsis in 4 patients and a drug-related death in 1, mild to moderate anorexia, vomiting, alopecia and renal dysfunction. These preliminary results suggest that treatment with methotrexate, vinblastine, doxorubicin and cisplatin is extremely effective against locoregional and disseminated urothelial tract tumors, with the expectation (95 per cent confidence limits) of inducing objective tumor regression in 53 to 89 per cent of the cases. © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByAbe T, Kitamura H, Obara W, Matsumura N, Tsukamoto T, Fujioka T, Hara I, Murai S, Shinohara N and Nonomura K (2018) Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in JapanJournal of Urology, VOL. 191, NO. 4, (932-936), Online publication date: 1-Apr-2014.DeCastro G and Steinberg G (2018) Are We Making Significant Progress in the Diagnosis and Management of Bladder Cancer?Journal of Urology, VOL. 183, NO. 5, (1667-1668), Online publication date: 1-May-2010.Margulis V, Youssef R, Karakiewicz P, Lotan Y, Wood C, 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Volume 133Issue 3March 1985Page: 403-407 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Cora N. Sternberg More articles by this author Alan Yagoda More articles by this author Howard I. Scher More articles by this author Robin C. Watson More articles by this author Tauseef Ahmed More articles by this author Lora R. Weiselberg More articles by this author Nancy Geller More articles by this author Phyllis S. Hollander More articles by this author Harry W. Herr More articles by this author Pramod C. Sogani More articles by this author Michael J. Morse More articles by this author Willet F. Whitmore More articles by this author Expand All Advertisement PDF DownloadLoading ...