Portal de Periódicos da CAPES

Choroidal Melanomas in Dogs

1985; SAGE Publishing; Volume: 22; Issue: 6 Linguagem: Inglês

10.1177/030098588502200612

1544-2217

Richard R. Dubielzig, Gustavo D. Aguirre, Simone Gross, R. W. Diters,

Virus-based gene therapy research

The clinical and morphological features of intraocular melanocytic masses that originated in the choroid of five dogs were compared. Two of the cases had been reported previously and the authors have examined the pathological material. Histologically, the choroidal melanocytic tumors had several features in common and appeared to be entities distinct from melanocytic tumors of the anterior uveal tract or the epibulbar region. The tumors were well-delineated with tapered edges. They occurred in the posterior quadrant and two tumors had infiltrated the optic nerve. The tumors contained plump, strap-like polyhedral cells, with minimal nuclear anaplasia and no mitotic figures. The retina overlying the tumor mass was detached, and the retinal pigment epithelium in this area was swollen and contained intracytoplasmic autofluorescent lipopigment. In two cases, the basement membrane of the retinal epithelium was disrupted by the tumor and pigmented cells infiltrated into the retina, the subretinal space, and the posterior chamber. In one case, retinal detachment was complete and accompanied by intraocular hemorrhage. Melanocytic tumors of the canine choroid have features in common with choroidal nevus and melanocytoma in human eyes.