Alkaline treatments to render starch-based biodegradable polymers self-mineralizable
2007; Wiley; Volume: 1; Issue: 6 Linguagem: Inglês
10.1002/term.54
ISSN1932-7005
AutoresIsabel B. Leonor, H.-M. Kim, Francisco Balas, Masakazu Kawashita, Rui L. Reis, Tadashi Kokubo, Takashi Nakamura,
Tópico(s)Facial Trauma and Fracture Management
ResumoJournal of Tissue Engineering and Regenerative MedicineVolume 1, Issue 6 p. 425-435 Research Article Alkaline treatments to render starch-based biodegradable polymers self-mineralizable I. B. Leonor, Corresponding Author I. B. Leonor [email protected] 3Bs Research Group, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal IBB—Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga, Portugal Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto Kasugai, Aichi 487-8501 Japan3Bs Research Group, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.Search for more papers by this authorH.-M. Kim, H.-M. Kim Department of Ceramic Engineering, School of Advanced Materials Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, KoreaSearch for more papers by this authorF. Balas, F. Balas Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto Kasugai, Aichi 487-8501 JapanSearch for more papers by this authorM. Kawashita, M. Kawashita Ion Beam Engineering Experimental Laboratory, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, JapanSearch for more papers by this authorR. L. Reis, R. L. Reis 3Bs Research Group, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal IBB—Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga, PortugalSearch for more papers by this authorT. Kokubo, T. Kokubo Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto Kasugai, Aichi 487-8501 JapanSearch for more papers by this authorT. Nakamura, T. Nakamura Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8506, JapanSearch for more papers by this author I. B. Leonor, Corresponding Author I. B. Leonor [email protected] 3Bs Research Group, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal IBB—Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga, Portugal Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto Kasugai, Aichi 487-8501 Japan3Bs Research Group, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.Search for more papers by this authorH.-M. Kim, H.-M. Kim Department of Ceramic Engineering, School of Advanced Materials Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, KoreaSearch for more papers by this authorF. Balas, F. Balas Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto Kasugai, Aichi 487-8501 JapanSearch for more papers by this authorM. Kawashita, M. Kawashita Ion Beam Engineering Experimental Laboratory, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, JapanSearch for more papers by this authorR. L. Reis, R. L. Reis 3Bs Research Group, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal IBB—Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga, PortugalSearch for more papers by this authorT. Kokubo, T. Kokubo Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto Kasugai, Aichi 487-8501 JapanSearch for more papers by this authorT. Nakamura, T. Nakamura Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8506, JapanSearch for more papers by this author First published: 08 January 2008 https://doi.org/10.1002/term.54Citations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The present research aims to develop a new route for surface functionalization of biodegradable polymers. The method is based on a wet chemistry modification, resulting in etching and/or hydrolysis in order to increase the amount of polar groups, such as hydroxyl (OH) and carboxylic (COOH) groups on the surface of the polymer. The polymer used as substrate was a corn starch–ethylene vinyl alcohol biodegradable blend (SEVA-C). For that purpose it was used in two different types of activation: (a) calcium hydroxide solution [Ca(OH)2] and (b) sodium hydroxide solution (NaOH). These treatments lead to the formation carboxylic acid-rich SEVA-C surfaces. Then, the samples were soaked in simulated body fluid (SBF) for different time periods of time until 7 days. After 1 day in SBF, the surface of SEVA-C was fully covered with spherulite particles. As the soaking time increased, the particles increased and coalesced, leading to the formation of a dense and uniform layer. Furthermore, thin-film X-ray diffraction confirms that the layer formed on the surface of the polymer was an apatite-like layer. These results suggest that this rather simple treatment is a good method for surface functionalization and subsequent mineral nucleation and growth on biodegradable polymeric surfaces to be used for bone-related applications. Copyright © 2008 John Wiley & Sons, Ltd. Citing Literature Volume1, Issue6November/December 2007Pages 425-435 RelatedInformation
Referência(s)