Nicotinamide overload may play a role in the developmentof type 2 diabetes
2009; Baishideng Publishing Group; Volume: 15; Issue: 45 Linguagem: Inglês
10.3748/wjg.15.5674
ISSN2219-2840
AutoresShi‐Sheng Zhou, Da Li, Wuping Sun, Ming Guo, Yongzhi Lun, Yiming Zhou, Fucheng Xiao, Jing Li-xin, Shenxia Sun, Libin Zhang, Ning Luo, Fu-Ning Bian, Wei Zou, Lai-Bin Dong, Zhigang Zhao, Sheng-Fan Li, Xiao‐Jie Gong, YU Zengguo, Chang-Bin Sun, Zheng Cong-long, Dong-Ju Jiang, Zhengning Li,
Tópico(s)Diet, Metabolism, and Disease
ResumoAIM:To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS:Nicotinamide metabolic patterns of 14 diabetic and 14 non-diabetic subjects were compared using HPLC.Cumulative effects of nicotinamide and N 1 -methylnicotinamide on glucose metabolism, plasma H2O2 levels and tissue nicotinamide adenine dinucleotide (NAD) contents of adult Sprague-Dawley rats were observed.The role of human sweat glands and rat skin in nicotinamide metabolism was investigated using sauna and burn injury, respectively.
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