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Vibrio cholerae Triggers SOS and Mutagenesis in Response to a Wide Range of Antibiotics: a Route towards Multiresistance

2011; American Society for Microbiology; Volume: 55; Issue: 5 Linguagem: Inglês

10.1128/aac.01549-10

1098-6596

Zeynep Baharoglu, Didier Mazel,

Bacterial Genetics and Biotechnology

ABSTRACT Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli , fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae . Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli , all these antibiotics induce SOS in V. cholerae .