Vedolizumab, a monoclonal antibody to the gut homing α4β7 integrin, does not affect cerebrospinal fluid T-lymphocyte immunophenotype
2013; Elsevier BV; Volume: 264; Issue: 1-2 Linguagem: Inglês
10.1016/j.jneuroim.2013.08.011
ISSN1872-8421
AutoresCatherine Milch, Tim Wyant, Jing Xu, Asit Parikh, Whitney Kent, Irving H. Fox, Joseph R. Berger,
Tópico(s)Multiple Sclerosis Research Studies
ResumoVedolizumab, a gut-homing α4β7 integrin antagonist, has demonstrated efficacy in ulcerative colitis and Crohn's disease. Development of progressive multifocal leukoencephalopathy, a serious brain infection associated with natalizumab (an α4β7 and α4β1 integrin antagonist), has raised concern that vedolizumab may convey a similar risk. Natalizumab is believed to impair central nervous system immune surveillance by affecting cerebrospinal fluid (CSF) lymphocyte counts and the CD4:CD8 ratio. To determine if vedolizumab elicits similar effects, we examined CSF of healthy volunteers by flow cytometry for T-lymphocyte surface markers 5 weeks after administration of intravenous vedolizumab 450 mg. No significant changes were observed in CSF T-lymphocyte populations.
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