The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
1994; Cell Press; Volume: 79; Issue: 6 Linguagem: Inglês
10.1016/0092-8674(94)90039-6
ISSN1097-4172
AutoresRichard Roy, J P Adamczewski, Thierry Seroz, Wim Vermeulen, Jean‐Pierre Tassan, Laurent Schaeffer, Erich A. Nigg, Jan H.J. Hoeijmakers, Jean‐Marc Egly,
Tópico(s)Genomics and Chromatin Dynamics
ResumoA protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.
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