An Assessment of Disability Rating Scales Used in Multiple Sclerosis
1991; American Medical Association; Volume: 48; Issue: 3 Linguagem: Inglês
10.1001/archneur.1991.00530150067020
ISSN1538-3687
AutoresD A Francis, Peter G. Bain, A V Swan, Richard A. Hughes,
Tópico(s)Rheumatoid Arthritis Research and Therapies
ResumoTwenty patients with clinically definite, stable multiple sclerosis were examined independently by three of us at the same visit and given scores on the Ambulation Index, Expanded Disability Status Scale, and Kurtzke Functional System scales. Observer error accounted for 12% to 55% of the variation observed between individual Kurtzke Functional System scores, 17.1% of the variation observed between the patients' Expanded Disability Status Scale scores, and only 3.9% of the variation between Ambulation Index scores. The implications of these findings for the choice of scales in clinical trials are described.
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