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BIBTEX RIS

Macrophage expression of class II major histocompatibility complex gene products in Paracoccidioides brasiliensis-infected mice.

1999; American Society of Tropical Medicine and Hygiene; Volume: 61; Issue: 2 Linguagem: Inglês

10.4269/ajtmh.1999.61.280

1476-1645

Anamélia Lorenzetti Bocca, M F Silva, Célio Lopes Silva, Fernando Q. Cunha, F. Figueiredo,

Toxoplasma gondii Research Studies

C57B1/6 isogenic mice infected with Paracoccidioides brasiliensis strains showed a disruption in the expression of Ia antigen. Expression slowly decreased during the course of the infection with a slight variation dependent on the route of inoculation and the fungal strain used, but production of interferon-gamma and tumor necrosis factor-alpha were observed. Suppression of Ia antigen expression and depression of the immunoproliferative responses of spleen cells were strongly correlated with nitric oxide levels. These parameters were inhibited when the animals were treated with nitro-L-arginine, which resulted in inhibition the activation of nitric oxide (NO) production. Analysis of the data showed that changes in the expression of the Ia antigen occur in P. brasiliensis infection and are strongly correlated with NO levels. These phenomena may be interrelated and reflect macrophage activation that contributes to the control of the disease and to the immunosuppression observed during the course of the infection.