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Tumor Necrosis Factor-α and Interleukin-1β Mediate the Production of Nitric Oxide Involved in the Pathogenesis of Ifosfamide Induced Hemorrhagic Cystitis in Mice
2002; Lippincott Williams & Wilkins; Volume: 167; Issue: 5 Linguagem: Inglês
10.1016/s0022-5347(05)65134-8
ISSN1527-3792
AutoresRita A. Ribeiro, H. Freitas, Míriam Cristina Alves de Oliveira Campos, Clisiane Carla de Souza Santos, Florêncio Figueiredo, Gerly Anne de Castro Brito, Fernando Q. Cunha,
Tópico(s)Liver physiology and pathology
ResumoNo AccessJournal of UrologyINVESTIGATIVE UROLOGY1 May 2002Tumor Necrosis Factor-α and Interleukin-1β Mediate the Production of Nitric Oxide Involved in the Pathogenesis of Ifosfamide Induced Hemorrhagic Cystitis in Mice R.A. RIBEIRO, H.C. FREITAS, M.C. CAMPOS, C.C. SANTOS, F.C. FIGUEIREDO, G.A.C. BRITO, and F.Q. CUNHA R.A. RIBEIROR.A. RIBEIRO , H.C. FREITASH.C. FREITAS , M.C. CAMPOSM.C. CAMPOS , C.C. SANTOSC.C. SANTOS , F.C. FIGUEIREDOF.C. FIGUEIREDO , G.A.C. BRITOG.A.C. BRITO , and F.Q. CUNHAF.Q. CUNHA View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65134-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the participation of nitric oxide in ifosfamide induced hemorrhagic cystitis in mice, and the involvement of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the induction of nitric oxide production in this model. Materials and Methods: Hemorrhagic cystitis was induced in mice by 100 to 400 mg./kg. ifosfamide and evaluated 6, 12, 24 or 48 hours thereafter by certain parameters, including vesical edema measurements, microscopic analysis and immunohistochemical testing for inducible nitric oxide synthase. Ifosfamide injected mice were pretreated with 10 to 40 mg./kg. of the nitric oxide synthesis inhibitor L-NG-nitroarginine methyl ester, 80 mg./kg. of mesna, a chemical antagonist of acrolein and the urotoxic metabolite of ifosfamide, 50 μl. antiserum against TNF-α and IL-1β per mouse, 45 mg./kg. of the selective TNF-α synthesis inhibitor thalidomide or 200 mg./kg. of the TNF-α and IL-1β synthesis inhibitor pentoxifylline. Results: Ifosfamide induced vesical edema, which peaked 12 hours after ifosfamide injection. Microscopic analysis revealed vascular congestion, edema, hemorrhage, fibrin deposition, neutrophil infiltration and epithelial denudation. Inducible nitric oxide synthase immunolocalization demonstrated intense reactivity to inducible nitric oxide synthase in the cytoplasm of bladder epithelial cells, which showed diffuse necrosis. Pretreatment with mesna reduced the increases in vesical edema, while treatment with L-NG-nitroarginine methyl ester, antiserum to TNF-α or IL-1β, thalidomide or pentoxifylline inhibited vesical edema and microscopic alterations. Antiserum treatments also inhibited the expression of inducible nitric oxide synthase in the urothelium. Conclusions: Nitric oxide produced by inducible nitric oxide synthase is involved in urothelial damage and in the inflammatory events leading to hemorrhagic cystitis after ifosfamide administration in mice. The induction of inducible nitric oxide synthase in the urothelium appears to depend on the synergistic effect of IL-1β and TNF-α. References 1 : Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs1991; 42: 428. Google Scholar 2 : Cyclophosphamide-induced hemorrhagic cystitis: a review of 100 patients. Cancer1988; 61: 451. Google Scholar 3 : Editorial: Hemorrhagic cystitis, chemotherapy, and bladder toxicity. J Urol1998; 159: 1044. Link, Google Scholar 4 : Comparative study on human pharmacokinetic of activated ifosfamide and cyclophosphamide by a modified fluorometric test. J Cancer Res Clin Oncol1981; 100: 95. Google Scholar 5 : Efficacy of ifosfamide in refractory malignant diseases and uroprotection by mesna: results of a clinical phase II study with 151 patients. Cancer Treat Rev1983; 10: 93. Google Scholar 6 : Cyclophosphamide cystitis-Identification of acrolein as the causative agent. Biochem Pharmacol1979; 28: 2045. Google Scholar 7 : The biology of alkylating-agent cellular injury. Hematol Oncol Clin North Am1993; 7: 325. Google Scholar 8 : Cyclophosphamide induced hemorrhagic cystitis. J Urol1999; 161: 1. Google Scholar 9 : Participation of TNF-α and IL-1 in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Braz J Med Biol Res1995; 28: 103. Google Scholar 10 : Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Am J Pathol1997; 150: 247. Google Scholar 11 : Prevention of cyclophosphamide-induced hemorrhagic cystitis by glucose-mannose binding plant lectins. J Urol1999; 161: 1988. Abstract, Google Scholar 12 : Studies on the urotoxicity of oxazaphorine cytostatics and its prevention. I. Experimental studies on the urotoxicity of alkylating compounds. Eur J Cancer1981; 17: 595. Google Scholar 13 : Evidence that nitric oxide modulates oedema formation by substance P. Eur J Pharmacol1990; 191: 481. Google Scholar 14 : Effects of NG-monomethyl-L-arginine and its D-enantiomer on rat hind paw oedema. In: Biology of Nitric Oxide: Physiological and Clinical Aspects.. Edited by . London: Portland Press1992: 264. Google Scholar 15 : Role of nitric oxide in modulating permeability of hamster cheeks pouch in response to adenosine 5-diphosphate and bradykinin. Inflammation1992; 16: 295. Google Scholar 16 : Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation. Proc Natl Acad Sci USA1994; 91: 2046. Google Scholar 17 : Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J Pharmacol Exp Ther1998; 284: 1203. Google Scholar 18 : Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol1992; 211: 177. Google Scholar 19 : Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-α and IL-1β. Immunology1994; 81: 211. Google Scholar 20 : Induction of nitric oxide synthase with urinary tract infections. Adv Exp Med Biol1999; 462: 359. Google Scholar 21 : Cytokine-mediated nitric oxide release-a common cytotoxic pathway in host-versus-graft and graft-versus-host reactions?. Bone Marrow Transplant1997; 20: 385. Google Scholar 22 : Altered immune responses in mice lacking inducible nitric oxide synthase. Nature1995; 375: 408. Google Scholar 23 : Inducible enzymes in the pathogenesis of rheumatoid arthritis. In: Inducible Enzymes in the Inflammatory Response.. Edited by . Switzerland: Birkhäuser-Verlag-Basel1999: 93. Google Scholar 24 : Interactions of nitric oxide and oxygen in cytotoxicity: proliferation and antioxidant enzyme activities of endothelial cells in culture. Free Radical Res2000; 33: 147. Google Scholar 25 : Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Free Radical Res1999; 31: 651. Google Scholar 26 : Cytotoxic versus genotoxic effects of nitric oxide (NO). Toxicol Lett1999; 106: 59. Google Scholar 27 : Involvement of resident macrophages and mast cells in the writing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol2000; 387: 111. Google Scholar 28 : Tumour necrosis factor-alpha and leukotriene B4 mediate the neutrophil migration in immune inflammation. Br J Pharmacol2001; 134: 1619. Google Scholar 29 : Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery1991; 110: 192. Google Scholar 30 : Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J Exp Med1991; 173: 699. Google Scholar 31 : Evidence for the involvement of bradykinin in chemically-evoked cystitis in anesthetized rats. Naunyn Sschiedebergs Arch Pharmacol1993; 347: 432. Google Scholar 32 Ribeiro, R.A., Souza-Filho, M.V.P., Santos, C.C., et al.: Involvement of nitric oxide and tumor necrosis factor in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Proc 17th Int Cancer Congr, 227, 1998. Google Scholar 33 : Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Cancer Res1997; 57: 472. Google Scholar 34 : IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. J Immunol1992; 148: 3578. Google Scholar From the Departments of Physiology and Pharmacology and Morphology, Faculty of Medicine, Federal University of Ceará, Department of Clinical Oncology, Cancer Institute of Ceará, Ceará, Department of Pathology, Faculty of Medicine, University of Brasília, Brasilia, D. F. and Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLeite C, Alencar V, Melo D, Mota J, Melo P, Mourão L, Wong D, Magalhães P, Santos A, Brito G, Lima-Júnior R, Cunha F and Ribeiro R (2015) Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic Cystitis in MiceJournal of Urology, VOL. 194, NO. 6, (1777-1786), Online publication date: 1-Dec-2015.Vykhovanets E, MacLennan G, Vykhovanets O, Cherullo E, Ponsky L and Gupta S (2011) Molecular Imaging of Nuclear Factor-κB in Bladder as a Primary Regulator of Inflammatory ResponseJournal of Urology, VOL. 187, NO. 1, (330-337), Online publication date: 1-Jan-2012.Hahn N (2009) Learning to Control Cyclophosphamide Induced CystitisJournal of Urology, VOL. 181, NO. 5, (1987-1988), Online publication date: 1-May-2009.Kiuchi H, Takao T, Yamamoto K, Nakayama J, Miyagawa Y, Tsujimura A, Nonomura N and Okuyama A (2009) Sesquiterpene Lactone Parthenolide Ameliorates Bladder Inflammation and Bladder Overactivity in Cyclophosphamide Induced Rat Cystitis Model by Inhibiting Nuclear Factor-κB PhosphorylationJournal of Urology, VOL. 181, NO. 5, (2339-2348), Online publication date: 1-May-2009.KORKMAZ A, OTER S, SADIR S, COSKUN O, TOPAL T, OZLER M and BILGIC H (2018) PEROXYNITRITE MAY BE INVOLVED IN BLADDER DAMAGE CAUSED BY CYCLOPHOSPHAMIDE IN RATSJournal of Urology, VOL. 173, NO. 5, (1793-1796), Online publication date: 1-May-2005.KORKMAZ A, OTER S, DEVECI S, OZGURTAS T, TOPAL T, SADIR S and BILGIC H (2018) Involvement of Nitric Oxide and Hyperbaric Oxygen in the Pathogenesis of Cyclophosphamide Induced Hemorrhagic Cystitis in RatsJournal of Urology, VOL. 170, NO. 6, (2498-2502), Online publication date: 1-Dec-2003. Volume 167Issue 5May 2002Page: 2229-2234 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsmicebladdercystitisnitric oxideifosfamideMetrics Author Information R.A. RIBEIRO More articles by this author H.C. FREITAS More articles by this author M.C. CAMPOS More articles by this author C.C. SANTOS More articles by this author F.C. FIGUEIREDO More articles by this author G.A.C. BRITO More articles by this author F.Q. CUNHA More articles by this author Expand All Advertisement PDF downloadLoading ...
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