Produção Nacional
Revisado por pares
Rates of and Reasons for Failure of Commercial Human Immunodeficiency Virus Type 1 Viral Load Assays in Brazil
2007; American Society for Microbiology; Volume: 45; Issue: 6 Linguagem: Inglês
10.1128/jcm.00136-07
ISSN1098-660X
AutoresJan Felix Drexler, Luciano Kleber de Souza Luna, Célia Pedroso, D Pedral-Sampaio, Artur T. L. Queiroz, Carlos Brites, Eduardo Martins Netto, Christian Drosten,
Tópico(s)HIV/AIDS Research and Interventions
ResumoWe examined failures of commercial human immunodeficiency virus type 1 (HIV-1) viral load assays of 1,195 plasma samples from Brazilian patients. Assay failure was assumed for samples in which the virus was undetectable by commercial assay but which tested positive by real-time reverse transcription-PCR of the HIV-1 long terminal repeat (LTR) region or if the viral load differed by >2 log10 from that determined by LTR assay. Failure rates for Bayer Versant bDNA 3.0, Roche Amplicor Monitor v1.5, and bioMerieux NucliSens QT were 0.68, 0.47, and 4.33%, respectively. NucliSens may be inadequate for use in Brazil.
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