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Phosphorylated PmrA Interacts with the Promoter Region of ugd in Salmonella enterica Serovar Typhimurium

2000; American Society for Microbiology; Volume: 182; Issue: 13 Linguagem: Inglês

10.1128/jb.182.13.3874-3876.2000

1098-5530

Andrés Aguirre, Sergio Lejona, Eleonora Garcı́a Véscovi, Fernando C. Soncini,

CRISPR and Genetic Engineering

ABSTRACT The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of PmrA with the promoter region of three of them was observed. Here we characterized the interaction of PmrA with the promoter region of ugd , previously suggested to be regulated indirectly by PmrA. Our results indicate that PmrA controls the expression of ugd by interacting with a specific sequence in the promoter region of this gene.