Clinical characteristics of severe peripheral neuropathy induced by docetaxel (Taxotere)
1997; Elsevier BV; Volume: 8; Issue: 2 Linguagem: Inglês
10.1023/a
ISSN1569-8041
AutoresP.H.E. Hilkens, Jaap Verweij, C. J. Vecht, G. Stoter, Martin J. van den Bent,
Tópico(s)Multiple Myeloma Research and Treatments
ResumoDocetaxel, a semi-synthetic taxane may cause a usually mild sensory neuropathy. We describe the clinical characteristics of five patients who developed a more severe neuropathy following treatment with docetaxel.All patients were treated in phase II studies with 100 mg/m2 docetaxel in three weekly cycles, without steroid administration.The clinical picture in these patients was dominated by a sensory neuropathy, but in one case severe weakness was present. Another patient developed Lhermitte's sign. Signs and symptoms are usually reversible after discontinuation of docetaxel administration, but in three patients symptoms worsened for some time after the end of treatment before improvement occurred.Severe docetaxel neuropathy may especially occur following treatment with cumulative dosage over 600 mg/m2; in patients treated with this dosage a moderate or severe neuropathy may not be rare.
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