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A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression

2010; Public Library of Science; Volume: 8; Issue: 9 Linguagem: Inglês

10.1371/journal.pbio.1000484

1545-7885

Ramona Pop, Jeffrey R. Shearstone, Qichang Shen, Ying Liu, Kelly Hallstrom, Miroslav Koulnis, Joost Gribnau, Merav Socolovsky,

RNA modifications and cancer

During red blood cell development, differentiation and cell cycle progression are intimately and uniquely linked through interdependent mechanisms involving the erythroid transcriptional suppressor PU.1 and the cyclin-dependent kinase inhibitor p57KIP2.