Artigo Acesso aberto Produção Nacional Revisado por pares

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

2013; Associação Brasileira de Divulgação Científica; Volume: 46; Issue: 7 Linguagem: Inglês

10.1590/1414-431x20132894

ISSN

1414-431X

Autores

D.A.C. Magro, M. Hohmann, Sandra S. Mizokami, Thiago M. Cunha, José C. Alves‐Filho, Rúbia Casagrande, S. H. Ferreira, Foo Y. Liew, Fernando Q. Cunha, Waldiceu A. Verri,

Tópico(s)

Fibromyalgia and Chronic Fatigue Syndrome Research

Resumo

Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors.

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