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Effect of Cytomegalovirus-Induced Immune Response, Self Antigen–Induced Immune Response, and Microbial Translocation on Chronic Immune Activation in Successfully Treated HIV Type 1–Infected Patients: The ANRS CO3 Aquitaine Cohort

2012; Oxford University Press; Volume: 207; Issue: 4 Linguagem: Inglês

10.1093/infdis/jis732

1537-6613

Linda Wittkop, Juliette Bitard, Estibaliz Lazaro, D. Neau, Fabrice Bonnet, P. Mercié, M. Dupon, Mojgan Hessamfar, Michel Ventura, Denis Malvy, François Dabis, Jean‐Luc Pellegrin, Jean‐François Moreau, Rodolphe Thiébaut, Isabelle Pellegrin, François Dabis, Fabrice Bonnet, Stéphane Bouchet, François Dabis, M. Dupon, Geneviève Chêne, Hélène Fleury, Valérie Gaborieau, D. Lacoste, Denis Malvy, P. Mercié, Isabelle Pellegrin, Philippe Morlat, D. Neau, Pellegrin Jl, S. Tchamgoué, Rodolphe Thiébaut, Mathias Bruyand, Geneviève Chêne, François Dabis, S. Lawson‐Ayayi, Rodolphe Thiébaut, Linda Wittkop, Keila Magalhães André, F. Bonnal, Fabrice Bonnet, N. Bernard, L. Caunègre, C. Cazanave, J. Ceccaldi, I. Chossat, C Courtault, Dauchy FA., De Witte S., M. Dupon, A. Dupont, P. Duffau, H. Dutronc, S. Farbos, Valérie Gaborieau, Gemain MC., Y Gérard, C. Greib, Mojgan Hessamfar, D. Lacoste, P. Lataste, Estibaliz Lazaro, M. Longy‐Boursier, Denis Malvy, J.-P. Méraud, P. Mercié, É. Monlun, Philippe Morlat, D. Neau, Augusto C. Ochoa, Jean‐Luc Pellegrin, T. Pistone, M. C. Receveur, J. Roger-Schmeltz, S. Tchamgoué, M.A. Vandenhende, Marc-Olivier Vareil, J.-F. Viallard, Jean‐François Moreau, Isabelle Pellegrin, Hélène Fleury, Marie‐Edith Lafon, Bernard Masquelier, Pascale Trimoulet, Dominique Breilh, Stéphane Bouchet, Mathiéu Molimard, Karine Titier, Françoise Haramburu, G. Miremont-Salamé, M. J. Blaizeau, M. Decoin, J. Delaune, S. Delveaux, C d'Ivernois, C. Hanappier, Olivier Leleux, E. Lenaud, B. Uwamaliya-Nziyumvira, X. Sicard, V. Conte, Adam Frosh, S. Geffard, J Leray, I. Louis, Gary A. Palmer, Dominique Touchard,

Immune Cell Function and Interaction

We evaluated the impact of cytomegalovirus (CMV)–induced immune responses, autoimmune-induced immune responses, and microbial translocation on immune activation in 191 human immunodeficiency virus type 1–infected patients from the ANRS CO3 Aquitaine Cohort. All enrolled subjects had achieved long-term virological suppression during receipt of combination antiretroviral therapy (cART). HLA-DR+/CD38+ expression was 16.8% among CD8+ T cells. Independent of age, CD4+ T-cell count, 16S ribosomal DNA load, and regulatory T-cell count, positive results of Quantiferon CMV analysis (P = .02), positive results of CMV-pp65 enzyme-linked immunosorbent spot analysis (P = .01), positive results of CMV-pp65–specific CD8+ T-cell analysis (P = .05), and CMV seropositivity (P = .01) were associated with a higher percentage of CD8+ T cells that expressed HLA-DR+/CD38+. Autoimmune response and microbial translocation were not associated with immune activation. Therefore, the CMV-induced immune response seems to be associated with chronic immune activation in cART recipients with sustained virological suppression.