Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

2015; American Association for the Advancement of Science; Volume: 350; Issue: 6264 Linguagem: Inglês

10.1126/science.aad1191

ISSN

1095-9203

Autores

Luhan Yang, Marc Güell, Dong Niu, Haydy George, Emal Lesha, Dennis Grishin, John Aach, Ellen Shrock, Weihong Xu, Jürgen Poci, Rebeca Cortazio, Robert A. Wilkinson, Jay A. Fishman, George M. Church,

Tópico(s)

Animal Genetics and Reproduction

Resumo

Virally cleansing the pig genome Transplants from pigs could be a solution to a shortage of human organs for transplantation. Unfortunately, porcine endogenous retroviruses (PERVs) are rife in pigs and can be transmitted to humans, risking disease. L. Yang et al. integrated CRISPR-Cas into the pig cell genome, where continuous induction of the Cas9 editing enzyme resulted in the mutation of every single PERV reverse transcriptase gene. This prevented replication of all copies of PERV, viral infection, and transmission to human cells. Science , this issue p. 1101

Referência(s)