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Epidemiological Study of the Association between Anti-Lutzomyia longipalpis Saliva Antibodies and Development of Delayed-Type Hypersensitivity to Leishmania Antigen

2010; American Society of Tropical Medicine and Hygiene; Volume: 83; Issue: 4 Linguagem: Inglês

10.4269/ajtmh.2010.10-0182

1476-1645

Dorlene Maria Cardoso de Aquino, A Caldas, José Carlos Miranda, Antônio Augusto Moura da Silva, Manoel Barral‐Netto, Aldina Barral,

Synthesis and Biological Evaluation

Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response.