Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Klebsiella pneumoniae with multiple antimicrobial resistance

2004; Elsevier BV; Volume: 8; Issue: 1 Linguagem: Inglês

10.1590/s1413-86702004000100008

ISSN

1678-4391

Autores

Carlos Maurício Cardeal Mendes, Carlos Roberto Veiga Kiffer, Adília Segura, Julival Ribeiro, Philip J. Turner,

Tópico(s)

Bacteriophages and microbial interactions

Resumo

A Klebsiella pneumoniae strain was isolated from the urine of a patient at one of the centers participating in the 2001 edition of the MYSTIC program in Brazil. The initial phenotypic findings of the isolated K. pneumoniae presented an unusual MIC of 8 mug/mL to meropenem, 2 mug/mL to imipenem, elevated MICs to broad spectrum cephalosporins (ceftazidime/cefotaxime/cefepime MIC > 256 mug/mL), aminoglycosides (gentamycin > 256 mug/mL and tobramycin = 48 mug/mL), piperacillin/tazobactam (MIC > 256 mug/mL) and susceptibility to ciprofloxacin (MIC = 0.25 mug/mL). The strain also tested positive for ESBL production with double-disk and E-test methodologies. More detailed investigation revealed that the strain produced a SHV-4 type enzyme and also lacked a 36 kDa outer membrane porin.

Referência(s)