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Penicillin in acute otitis media: a double-blind placebo-controlled trial

1981; Wiley; Volume: 6; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2273.1981.tb01781.x

1749-4486

Niels Mygind, K.-I. Meistrup-Larsen, J. Thomsen, Villy Frølund Thomsen, Kenneth Josefsson, Henrik Toft Sørensen,

Bacterial Infections and Vaccines

Clinical Otolaryngology & Allied SciencesVolume 6, Issue 1 p. 5-13 Penicillin in acute otitis media: a double-blind placebo-controlled trial† N. MYGIND, Corresponding Author N. MYGIND University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkNiels Mygind, Otpathological Laboratory, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.Search for more papers by this authorK.-I. MEISTRUP-LARSEN, K.-I. MEISTRUP-LARSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this authorJ. THOMSEN, J. THOMSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this authorV. F. THOMSEN, V. F. THOMSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this authorK. JOSEFSSON, K. JOSEFSSON *Medical Department, Astra Pharmaceuticals, Södertülje, SwedenSearch for more papers by this authorH. SØRENSEN, H. SØRENSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this author N. MYGIND, Corresponding Author N. MYGIND University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkNiels Mygind, Otpathological Laboratory, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.Search for more papers by this authorK.-I. MEISTRUP-LARSEN, K.-I. MEISTRUP-LARSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this authorJ. THOMSEN, J. THOMSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this authorV. F. THOMSEN, V. F. THOMSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this authorK. JOSEFSSON, K. JOSEFSSON *Medical Department, Astra Pharmaceuticals, Södertülje, SwedenSearch for more papers by this authorH. SØRENSEN, H. SØRENSEN University Department of Otology, Hvidovre Hospital, Department of Bacteriology, Kommunehospitalet, Copenhagen, DenmarkSearch for more papers by this author First published: February 1981 https://doi.org/10.1111/j.1365-2273.1981.tb01781.xCitations: 94 † †Read at the Oto-Rhino-Laryngological Research Society meeting, Manchester, October 1978. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat ABSTRACT The effect of peroral penicillin-V (55 mg/kg/day in 7 days)on acute otitis media was studied in 149 children between the ages of 1 and 10 years in a double-blind, placebo-controlled investigation. The parameters of the disease employed were symptom scores for earache, fever and common cold, the use of analgetics, otoscopy, as well as tympanometry. The children were followed-up for 3 months. Penicillin had no effect on fever and common cold, but earache was significantly reduced on the 2nd day of treatment. The acute course of the disease was satisfactory in 69% of the children in the placebo group and in 86% in the penicillin group. In patients with pneumococci or haemolytic streptococci in the nasopharynx, the pain disappeared after 1–2 doses of penicillin, whereas the treatment had no effect in children with Haemophilus influenzae There was no difference between the penicillin and the placebo groups with regard to the results of otoscopy and tympanometry after 1 week, 1 month and 3 months. No serious complications were observed. It is concluded that an attitude of ‘masterly inactivity’ with regard to the treatment of acute otitis media is justifiable, provided sufficient analgesic treatment is given and also that the patient can be closely followed. As there are still many unanswered questions more controlled investigations are warrented. Citing Literature Volume6, Issue1February 1981Pages 5-13 RelatedInformation